Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | STAT1 | P42224 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30578824 | 0.75 | ALDH1A1 (0.54) | TSHRRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL29353713 | 0.75 | SMN1; SMN2 (0.64) | TSHRRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL150084 | 0.74 | LCK (0.58) | — | |
| SCHEMBL16757197 | 0.73 | RAB9A (0.44) | RAB9AALDH1A1SMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL29356907 | 0.72 | TSHR (0.54) | TSHRRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL48387 | 0.72 | ALDH1A1 (0.53) | RAB9AALDH1A1NPC1CYP1A2CYP2C19 | |
| SCHEMBL994563 | 0.72 | RAB9A (0.55) | TSHRRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL18284453 | 0.71 | RAB9A (0.49) | TSHRRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL20843709 | 0.71 | L3MBTL1 (0.48) | TSHRRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL6675218 | 0.71 | TSHR (0.56) | TSHRRAB9AALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391602-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010080481-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |