Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3781276 | 1.00 | HSD17B10 (0.36) | HSD17B10CHRM2CHRM1CHRM3ATM | |
| SCHEMBL29039261 | 0.92 | HSD17B10 (0.43) | HSD17B10ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL2490765 | 0.92 | HSD17B10 (0.43) | HSD17B10ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL3771067 | 0.92 | HSD17B10 (0.43) | HSD17B10ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL3763846 | 0.90 | PDE8B (0.43) | HSD17B10ATMHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL2569371 | 0.88 | HSD17B10 (0.39) | HSD17B10CHRM2CHRM1CHRM3ATM | |
| SCHEMBL3768956 | 0.88 | HSD17B10 (0.39) | HSD17B10CHRM2CHRM1CHRM3ATM | |
| SCHEMBL2569354 | 0.88 | HSD17B10 (0.32) | HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL5160976 | 0.83 | SMN1; SMN2 (0.37) | HSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL14048047 | 0.82 | PDK1 (0.43) | ATMPARP1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8435978-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2013-05-07 | — | — | US | disclosed |
| US-20100324009-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2010-12-23 | — | — | US | disclosed |
| US-20100317644-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2010-12-16 | — | — | US | disclosed |
| US-20080153843-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317644-A1 | Substituted Sulfonamide Compounds | SULT2A1, STS, SULT1A1 | HSD17B10 3104/4885CHRM2 4235/4885CHRM1 4618/4885 |
| US-20100324009-A1 | Substituted Sulfonamide Compounds | SULT2A1, STS, SULT1A1 | HSD17B10 3104/4885CHRM2 4235/4885CHRM1 4618/4885 |
| US-20080153843-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | SULT2A1, STS, SULT1A1 | HSD17B10 3104/4885CHRM2 4235/4885CHRM1 4618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.