SCHEMBL3781740

SCHEMBL3781740

O=C1N=CNC1=Cc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.46
MAPK1 P28482 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HSD17B10 Q99714 1/20 0.46
HPGD P15428 4/20 0.43
MAPT P10636 3/20 0.43
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
HTT P42858 2/20 0.43
ALPL P05186 1/20 0.39
ALPI P09923 1/20 0.39
CYP1A2 P05177 2/20 0.38
PIM1 P11309 1/20 0.38
PIM3 Q86V86 1/20 0.38
PIM2 Q9P1W9 1/20 0.38
TDP1 Q9NUW8 2/20 0.37
KDM4E B2RXH2 3/20 0.36
NPSR1 Q6W5P4 1/20 0.36
F3 P13726 1/20 0.36
POLB P06746 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrogen Peroxide SCHEMBL29033947 0.84 GSK3B (0.49) LMNAHPGDMAPTMEN1KMT2A
SCHEMBL132172 0.81 GSK3B (0.50) LMNAHPGDMAPTMEN1KMT2A
SCHEMBL132173 0.81 GSK3B (0.50) LMNAHPGDMAPTMEN1KMT2A
SCHEMBL16111885 0.78 MAPT (0.54) LMNAMAPK1SMN1; SMN2HPGDMAPT
SCHEMBL128473 0.71 MAPT (0.50) LMNASMN1; SMN2HPGDMAPTMEN1
SCHEMBL5003596 0.71 MAPT (0.50) LMNASMN1; SMN2HPGDMAPTMEN1
SCHEMBL128472 0.71 MAPT (0.50) LMNASMN1; SMN2HPGDMAPTMEN1
SCHEMBL15954810 0.70 LRRK2 (0.38) MAPTMEN1KMT2AKDM4EALDH1A1
SCHEMBL11851323 0.69 LMNA (0.50) LMNAMAPK1SMN1; SMN2HSD17B10HPGD
SCHEMBL11851316 0.69 LMNA (0.50) LMNAMAPK1SMN1; SMN2HSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10598667-B2 Functional illumination in living cells THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-03-24 US claimed
US-20160313341-A1 FUNCTIONAL ILLUMINATION IN LIVING CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2016-10-27 US claimed
WO-2014160752-A2 FUNCTIONAL ILLUMINATION IN LIVING CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-10-02 WO claimed
WO-2024211779-A1 AFFINITY PEPTIDES FOR DIAGNOSIS AND TREATMENT OF VIRAL INFECTIONS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-10-10 WO disclosed
US-11629131-B2 Coupled recognition/detection system for in vivo and in vitro use CORNELL UNIVERSITY (US) 2023-04-18 US disclosed
US-20220387633-A1 SMART PEPTIDES AND TRANSFORMABLE NANOPARTICLES FOR CANCER IMMUNOTHERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-12-08 US disclosed
EP-4013460-A2 SMART PEPTIDES AND TRANSFORMABLE NANOPARTICLES FOR CANCER IMMUNOTHERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-06-22 EP disclosed
WO-2021030743-A2 SMART PEPTIDES AND TRANSFORMABLE NANOPARTICLES FOR CANCER IMMUNOTHERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-02-18 WO disclosed
US-10598667-B2 Functional illumination in living cells THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-03-24 US disclosed
US-20190185434-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE UNIV CORNELL (US) 2019-06-20 US disclosed
US-10316000-B2 Coupled recognition/detection system for in vivo and in vitro use CORNELL UNIVERSITY (US) 2019-06-11 US disclosed
EP-2398775-B1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE UNIV CORNELL (US) 2019-04-24 EP disclosed
US-20160313341-A1 FUNCTIONAL ILLUMINATION IN LIVING CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2016-10-27 US disclosed
WO-2014160752-A2 FUNCTIONAL ILLUMINATION IN LIVING CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-10-02 WO disclosed
US-20120252699-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE CORNELL UNIVERSITY (US) 2012-10-04 US disclosed
EP-2398775-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE Cornell University (US) 2011-12-28 EP disclosed
WO-2010096584-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE CORNELL UNIVERSITY (US) 2010-08-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220387633-A1 SMART PEPTIDES AND TRANSFORMABLE NANOPARTICLES FOR CANCER IMMUNOTHERAPY ERBB2, FOLR2, EGFR LMNA 1549/4885MAPK1 2237/4885SMN1; SMN2 3728/4885
US-11629131-B2 Coupled recognition/detection system for in vivo and in vitro use DCLRE1B, TLR9, APEX1 LMNA 654/4885MAPK1 3640/4885SMN1; SMN2 4021/4885
US-10316000-B2 Coupled recognition/detection system for in vivo and in vitro use DCLRE1B, TLR9, APEX1 LMNA 654/4885MAPK1 3640/4885SMN1; SMN2 4021/4885
US-20120252699-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE DCLRE1B, TLR9, APEX1 LMNA 654/4885MAPK1 3640/4885SMN1; SMN2 4021/4885
US-20190185434-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE DCLRE1B, TLR9, APEX1 LMNA 654/4885MAPK1 3640/4885SMN1; SMN2 4021/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.