Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10252332 | 0.83 | PTGS2 (0.36) | PTGS2PTGS1STAT3KMT2AMEN1 | |
| SCHEMBL26970921 | 0.80 | ALDH1A1 (0.36) | PTGS2PTGS1STAT3KMT2AMEN1 | |
| SCHEMBL776071 | 0.80 | CA1 (0.45) | STAT3KMT2AMEN1CA1CA9 | |
| SCHEMBL464388 | 0.77 | MEN1 (0.43) | STAT3KMT2AMEN1CA1CA9 | |
| SCHEMBL7909564 | 0.75 | CA2 (0.54) | STAT3KMT2AMEN1CA1CA9 | |
| SCHEMBL21407644 | 0.74 | CA1 (0.45) | STAT3KMT2AMEN1CA1CA9 | |
| SCHEMBL25462640 | 0.73 | PSEN1 (0.46) | PTGS2PTGS1KMT2AMEN1ALDH1A1 | |
| SCHEMBL29051355 | 0.73 | PTGS2 (0.39) | PTGS2PTGS1ALDH1A1GAALMNA | |
| SCHEMBL17468133 | 0.73 | CA12 (0.35) | PTGS2PTGS1STAT3KMT2AMEN1 | |
| SCHEMBL778393 | 0.73 | ALDH1A1 (0.56) | KMT2AMEN1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371298-B2 | Processes for the preparation of isothiazole derivatives | PFIZER INC. (US) | 2016-06-21 | — | — | US | disclosed |
| US-9371298-B2 | Processes for the preparation of isothiazole derivatives | PFIZER INC. (US) | 2016-06-21 | — | — | US | disclosed |
| US-9371298-B2 | Processes for the preparation of isothiazole derivatives | PFIZER INC. (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150065726-A1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | PFIZER INC. | 2015-03-05 | — | — | US | disclosed |
| US-20150065726-A1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | PFIZER INC. | 2015-03-05 | — | — | US | disclosed |
| US-20150065726-A1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | PFIZER INC. | 2015-03-05 | — | — | US | disclosed |
| US-8884025-B2 | Processes for the preparation of isothiazole derivatives | PFIZER INC. | 2014-11-11 | — | — | US | disclosed |
| US-8884025-B2 | Processes for the preparation of isothiazole derivatives | PFIZER INC. | 2014-11-11 | — | — | US | disclosed |
| US-8884025-B2 | Processes for the preparation of isothiazole derivatives | PFIZER INC. | 2014-11-11 | — | — | US | disclosed |
| EP-1784183-B1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | PFIZER (US) | 2012-01-25 | — | — | EP | disclosed |
| US-20090023924-A1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | PFIZER INC. | 2009-01-22 | — | — | US | disclosed |
| US-20090023924-A1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | PFIZER INC. | 2009-01-22 | — | — | US | disclosed |
| US-20090023924-A1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | PFIZER INC. | 2009-01-22 | — | — | US | disclosed |
| EP-1784183-A2 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | Pfizer Products Incorporated (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006026034-A2 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2006-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023924-A1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | CYP3A4, CYP3A43, CYP2F1 | PTGS2 2240/4885PTGS1 1111/4885STAT3 2239/4885 |
| US-20150065726-A1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | CYP3A4, CYP3A43, CYP2F1 | PTGS2 2437/4885PTGS1 1373/4885STAT3 1737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.