Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PKLR | P30613 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15595109 | 0.96 | PKLR (0.45) | PDK2PKLRTACR1GPR119TSHR | |
| SCHEMBL2782630 | 0.90 | PDK2 (0.44) | PDK2PKLRTACR1GPR119TSHR | |
| SCHEMBL6160222 | 0.86 | OPRM1 (0.53) | PDK2PKLRGPR119TSHRALOX15 | |
| SCHEMBL3326302 | 0.83 | PDK2 (0.50) | PDK2TACR1GPR119TSHRALOX15 | |
| SCHEMBL1513306 | 0.83 | PDK2 (0.49) | PDK2TACR1GPR119TSHRALOX15 | |
| SCHEMBL1106925 | 0.81 | OPRD1 (0.42) | PDK2TACR1GPR119TSHRALOX15 | |
| SCHEMBL3249913 | 0.81 | OPRD1 (0.49) | PDK2TACR1GPR119TSHRALOX15 | |
| SCHEMBL15807268 | 0.81 | PDK2 (0.42) | PDK2TACR1GPR119TSHRALOX15 | |
| SCHEMBL4699744 | 0.81 | ALDH1A1 (0.47) | PDK2GPR119TSHRALOX15ATM | |
| SCHEMBL6918765 | 0.81 | OPRM1 (0.47) | PDK2PKLRGPR119TSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |