Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | CPB1 | P15086 | 1/20 | 0.44 |
| ▸ | PEPD | P12955 | 1/20 | 0.44 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4245807 | 1.00 | POLB (0.49) | POLBFKBP1ANPSR1PREPMITF | |
| SCHEMBL4245806 | 1.00 | POLB (0.49) | POLBFKBP1ANPSR1PREPMITF | |
| SCHEMBL3793417 | 1.00 | POLB (0.49) | POLBFKBP1ANPSR1PREPMITF | |
| SCHEMBL3788934 | 1.00 | POLB (0.49) | POLBFKBP1ANPSR1PREPMITF | |
| SCHEMBL1336271 | 1.00 | POLB (0.49) | POLBFKBP1ANPSR1PREPMITF | |
| SCHEMBL21874256 | 0.87 | NPC1 (0.49) | POLBNPC1RAB9ASMN1; SMN2PDK1 | |
| SCHEMBL1150913 | 0.87 | NPC1 (0.49) | POLBNPC1RAB9ASMN1; SMN2PDK1 | |
| SCHEMBL9940046 | 0.87 | NPC1 (0.49) | POLBNPC1RAB9ASMN1; SMN2PDK1 | |
| SCHEMBL11450804 | 0.87 | NPC1 (0.49) | POLBNPC1RAB9ASMN1; SMN2PDK1 | |
| SCHEMBL2499400 | 0.87 | NPC1 (0.49) | POLBNPC1RAB9ASMN1; SMN2PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250136582-A1 | SELECT KRAS G12C INHIBITORS AND USES THEREOF | 1200 PHARMA LLC (US) | 2025-05-01 | — | — | US | disclosed |
| CN-119156383-A | Selective KRAS G12C inhibitors and uses thereof | 1200药业有限责任公司 | 2024-12-17 | — | — | CN | disclosed |
| WO-2023086383-A1 | SELECT KRAS G12C INHIBITORS AND USES THEREOF | 1200 PHARMA LLC (US) | 2023-05-19 | — | — | WO | disclosed |
| US-20100174096-A1 | Methods for Production of Optically Active Fluoropyrrolidine Derivatives | IM&T RESEARCH, INC. (US) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250136582-A1 | SELECT KRAS G12C INHIBITORS AND USES THEREOF | KRAS, NRAS, HRAS | POLB 1870/4885FKBP1A 1508/4885NPSR1 4792/4885 |
| US-20100174096-A1 | Methods for Production of Optically Active Fluoropyrrolidine Derivatives | QDPR, FDPS, DPYD | POLB 1745/4885FKBP1A 2321/4885NPSR1 2672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.