Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL11787722 | 0.95 | CA1 (0.32) | MAPTSMN1; SMN2KDM4EALOX15CA2 | |
| SCHEMBL28706832 | 0.91 | NPSR1 (0.31) | — | |
| SCHEMBL28672601 | 0.91 | MAPT (0.34) | MAPTSMN1; SMN2KDM4EALOX15 | |
| SCHEMBL28108953 | 0.89 | CYP1A2 (0.44) | USP2CYP1A2CYP2C9HPGDMAPK1 | |
| Diethylaminoethanol SCHEMBL28833693 | 0.89 | CYP1A2 (0.39) | USP2TSHRCYP1A2CYP2C9HPGD | |
| Trolamine SCHEMBL129129 | 0.85 | MAPT (0.33) | MAPTSMN1; SMN2KDM4EALOX15USP2 | |
| SCHEMBL5466971 | 0.84 | KDM5A (0.37) | SMN1; SMN2CA2TSHRHSD17B10 | |
| SCHEMBL28520460 | 0.84 | KDM5A (0.37) | SMN1; SMN2CA2TSHRHSD17B10 | |
| SCHEMBL6249184 | 0.83 | MAPT (0.38) | MAPTSMN1; SMN2 | |
| Dimethylaminoethanol SCHEMBL7791043 | 0.83 | MAPT (0.57) | MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 385 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12252752-B2 | Process for tanning leathers, pre-tanning products and use thereof | SILVATEAM S.P.A. (IT) | 2025-03-18 | — | — | US | claimed |
| EP-3636732-B1 | FABRIC SOFTENING COMPOSITIONS | COLGATE PALMOLIVE CO (US) | 2024-01-31 | — | — | EP | claimed |
| EP-4060054-B1 | PRODUCTS FOR THE TANNING OF LEATHERS, PRE-TANNING PRODUCTS AND USE THEREOF | SILVATEAM S P A (IT) | 2023-11-15 | — | — | EP | claimed |
| US-20220298590-A1 | PROCESS FOR TANNING LEATHERS, PRE-TANNING PRODUCTS AND USE THEREOF | SILVATEAM S.P.A. (IT) | 2022-09-22 | — | — | US | claimed |
| EP-4060054-A1 | PRODUCTS FOR THE TANNING OF LEATHERS, PRE-TANNING PRODUCTS AND USE THEREOF | Silvateam S.p.A. (IT) | 2022-09-21 | — | — | EP | claimed |
| CN-115074467-A | Leather tanning process, anionic active agent composition, use of cationic active agents for the pre-tanning of leather and tanned leather | 施华团队股份公司 | 2022-09-20 | — | — | CN | claimed |
| EP-3383987-B1 | FABRIC SOFTENING COMPOSITIONS | COLGATE PALMOLIVE CO (US) | 2020-02-05 | — | — | EP | claimed |
| CN-106085639-A | A kind of pcb board waterborne cleaning agent and using method thereof | 昆山艾森半导体材料有限公司 | 2016-11-09 | — | — | CN | claimed |
| EP-1812540-B1 | FABRIC TREATMENT COMPOSITION | UNILEVER PLC (GB) | 2010-12-08 | — | — | EP | claimed |
| EP-1765966-B1 | FABRIC SOFTENING COMPOSITION | UNILEVER PLC (GB) | 2010-10-13 | — | — | EP | claimed |
| US-20100075890-A1 | Fabric Softening Composition | THE SUN PRODUCTS CORPORATION (US) | 2010-03-25 | — | — | US | claimed |
| US-7662766-B2 | Fabric softening composition | THE SUN PRODUCTS CORPORATION (US) | 2010-02-16 | — | — | US | claimed |
| US-20080305984-A1 | Fabric Softening Composition | Henkel IP & Holding GmbH (DE) | 2008-12-11 | — | — | US | claimed |
| EP-1765966-A1 | FABRIC SOFTENING COMPOSITION | Unilever Plc (GB) | 2007-03-28 | — | — | EP | claimed |
| US-20060254000-A1 | Composition for permanent dyeing of keratinous fibers | EUGENE PERMA FRANCE (FR) | 2006-11-16 | — | — | US | claimed |
| EP-1587488-B1 | COMPOSITION FOR PERMANENT DYEING OF KERATINOUS FIBERS | EUGENE PERMA FRANCE (FR) | 2006-09-13 | — | — | EP | claimed |
| WO-2006005480-A1 | FABRIC SOFTENING COMPOSITION | UNILEVER PLC (GB) | 2006-01-19 | — | — | WO | claimed |
| CN-119895020-A | Laundry compositions | 联合利华知识产权控股有限公司 | 2025-04-25 | — | — | CN | disclosed |
| EP-1323818-A1 | Use of fabric conditioning compositions comprising a quaternary ammonium compound | UNILEVER PLC (GB) | 2003-07-02 | — | — | EP | disclosed |
| WO-2003052035-A1 | USE OF FABRIC CONDITIONING COMPOSITIONS COMPRISING A QUATERNARY AMMONIUM COMPOUND | UNILEVER PLC (GB) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060254000-A1 | Composition for permanent dyeing of keratinous fibers | KRT18, DOT1L, PHYKPL | MAPT 932/4885SMN1; SMN2 4379/4885KDM4E 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.