Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 2/20 | 0.49 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | PREP | P48147 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371906 | 1.00 | ALDH1A1 (0.55) | ALDH1A1CYP3A4TSHRADORA3ADORA2A | |
| SCHEMBL6017607 | 0.91 | ACE (0.54) | ALDH1A1CYP3A4TSHRADORA3ADORA2A | |
| SCHEMBL3104909 | 0.90 | LTA4H (0.48) | ALDH1A1CYP3A4TSHRADORA3ADORA2A | |
| SCHEMBL4044966 | 0.88 | ALDH1A1 (0.51) | ALDH1A1CYP3A4TSHRADORA3ADORA2A | |
| SCHEMBL372167 | 0.88 | ALDH1A1 (0.51) | ALDH1A1CYP3A4TSHRADORA3ADORA2A | |
| SCHEMBL373946 | 0.85 | CYP3A4 (0.53) | ALDH1A1CYP3A4TSHRADORA3ADORA2A | |
| SCHEMBL16692005 | 0.84 | MMEL1 (0.54) | ALDH1A1CYP3A4TSHRADORA3ADORA2A | |
| SCHEMBL18065507 | 0.84 | MMEL1 (0.54) | ALDH1A1CYP3A4TSHRADORA3ADORA2A | |
| SCHEMBL26090328 | 0.81 | SYK (0.48) | ALDH1A1CYP3A4TSHRADORA3ADORA2A | |
| SCHEMBL26090330 | 0.81 | SYK (0.48) | ALDH1A1CYP3A4TSHRADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118724-A1 | Receptor-Type Kinase Modulators and Methods of Use | SYMPHONY EVOLUTION, INC. (US) | 2018-05-03 | — | — | US | disclosed |
| EP-2609919-A2 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| EP-2409704-A2 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-1874759-A4 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1874759-A1 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006108059-A1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2006-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118724-A1 | Receptor-Type Kinase Modulators and Methods of Use | EGFR, EPHA2, ERBB4 | ALDH1A1 3477/4885CYP3A4 3829/4885TSHR 1640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.