Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 4/20 | 0.35 |
| ▸ | PRKCB | P05771 | 3/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | STK10 | O94804 | 1/20 | 0.35 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.33 |
| ▸ | PRKCG | P05129 | 2/20 | 0.33 |
| ▸ | PRKCH | P24723 | 2/20 | 0.33 |
| ▸ | PRKCI | P41743 | 2/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.33 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3600677 | 0.80 | KDM4E (0.46) | PRKCAPRKCBGSK3BPTPRCPRKD3 | |
| SCHEMBL1127976 | 0.74 | GSK3B (0.56) | PRKCAPRKCBGSK3BPRKCGPRKCZ | |
| SCHEMBL6344247 | 0.73 | MGLL (0.44) | ALOX5PTPRCKDRPRKDCGLO1 | |
| SCHEMBL5758398 | 0.70 | PRKCA (0.74) | PRKCAPRKCBGSK3BKDRPRKCG | |
| SCHEMBL6344338 | 0.69 | GSK3B (0.41) | PRKCAPRKCBGSK3BPTPRCPRKCG | |
| SCHEMBL4848432 | 0.68 | CDK2 (0.39) | PRKCAPRKCBGSK3BPRKCGCAMK2D | |
| SCHEMBL5879232 | 0.67 | CCNE2 (0.63) | PRKCAGSK3BPTPRC | |
| SCHEMBL29504831 | 0.67 | CCNE2 (0.63) | PRKCAGSK3BPTPRC | |
| SCHEMBL2954257 | 0.67 | GSK3B (0.43) | PRKCAPRKCBGSK3BPTPRCPRKD3 | |
| Hydrochloric Acid SCHEMBL29664072 | 0.66 | CCNE2 (0.61) | PRKCAGSK3BPTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855203-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-20080096949-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096949-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | MAP2K2, MAP3K20, MAP2K3 | ALOX5 4672/4885PRKCA 43/4885PRKCB 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.