Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | IL2 | P60568 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16416435 | 0.89 | PRMT5 (0.33) | — | |
| SCHEMBL22749598 | 0.86 | — | — | |
| SCHEMBL23012286 | 0.79 | DAO (0.33) | DAOLRRK2 | |
| SCHEMBL15556927 | 0.79 | OPRL1 (0.33) | DAOLRRK2 | |
| SCHEMBL1559055 | 0.79 | IRAK4 (0.33) | DAO | |
| SCHEMBL4539279 | 0.77 | MAPT (0.38) | DAOCFTR | |
| SCHEMBL21616804 | 0.75 | PRKAB2 (0.39) | DAO | |
| SCHEMBL21960911 | 0.72 | LRRK2 (0.39) | CFTRLRRK2 | |
| SCHEMBL17713790 | 0.72 | PRKAG1 (0.31) | — | |
| SCHEMBL28882155 | 0.70 | MAPK1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265270-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009099982-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |