Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A2 | P31639 | 2/20 | 0.47 |
| ▸ | PYGL | P06737 | 6/20 | 0.43 |
| ▸ | PNP | P00491 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563761 | 1.00 | SLC5A2 (0.47) | SLC5A2PYGLPNPALDH1A1KDM4E | |
| SCHEMBL1444855 | 1.00 | SLC5A2 (0.47) | SLC5A2PYGLPNPALDH1A1KDM4E | |
| SCHEMBL7024599 | 1.00 | SLC5A2 (0.47) | SLC5A2PYGLPNPALDH1A1KDM4E | |
| SCHEMBL16718948 | 0.77 | NLRP3 (0.35) | SLC5A2 | |
| Ribose (Furanose) SCHEMBL8833 | 0.76 | LMNA (0.49) | PNPALDH1A1GMNNLMNABLM | |
| Ribose (Furanose) SCHEMBL3341287 | 0.76 | LMNA (0.49) | PNPALDH1A1GMNNLMNABLM | |
| Ribose (Furanose) SCHEMBL142622 | 0.76 | LMNA (0.49) | PNPALDH1A1GMNNLMNABLM | |
| Ribose (Furanose) SCHEMBL2325834 | 0.76 | LMNA (0.49) | PNPALDH1A1GMNNLMNABLM | |
| SCHEMBL9751247 | 0.75 | ADRB1 (0.38) | LMNASMN1; SMN2 | |
| SCHEMBL8663124 | 0.75 | ADRB1 (0.38) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170827-A2 | PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS | CYLENE PHARMACEUTICALS, INC. (US) | 2012-12-13 | — | — | WO | disclosed |
| WO-2010077310-A2 | AMIDE DERIVATIVES OF ETHACRYNIC ACID | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-08 | — | — | WO | disclosed |
| EP-1942937-A1 | ANTINEOPLASTIC COMBINATIONS WITH MTOR INHIBITOR, HERCEPTIN, AND/OR HKI-272 | Wyeth (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007056118-A1 | ANTINEOPLASTIC COMBINATIONS WITH MTOR INHIBITOR, HERCEPTIN, AND/OR HKI-272 | WYETH (US) | 2007-05-18 | — | — | WO | disclosed |