Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | DUSP22 | Q9NRW4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8535665 | 0.85 | CISD1 (0.60) | MAOAMAOBCISD1MEN1KMT2A | |
| SCHEMBL7456392 | 0.73 | CISD1 (0.53) | MAOAMAOBCISD1AKR1B1THRB | |
| SCHEMBL5145722 | 0.73 | CISD1 (0.53) | MAOAMAOBCISD1AKR1B1THRB | |
| SCHEMBL11321794 | 0.73 | CISD1 (0.71) | MAOAMAOBCISD1THRBKDM4E | |
| SCHEMBL27931454 | 0.73 | CISD1 (0.53) | MAOAMAOBCISD1AKR1B1THRB | |
| SCHEMBL8388794 | 0.73 | CISD1 (0.71) | MAOAMAOBCISD1THRBKDM4E | |
| SCHEMBL7464201 | 0.73 | CISD1 (0.71) | MAOAMAOBCISD1THRBKDM4E | |
| SCHEMBL9911664 | 0.72 | MEN1 (0.62) | MAOAMAOBCISD1THRBMEN1 | |
| SCHEMBL8012606 | 0.70 | MAPT (0.44) | MEN1KMT2APTPN1PIM1PIM3 | |
| SCHEMBL14527005 | 0.70 | ALDH1A1 (0.67) | MAOAMAOBCISD1AKR1B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010082212-A2 | N-BIPHENYLACYL THIAZOLIDINE-2,4-DIONE DERIVATIVES, THEIR SYNTHESIS AND USES | ELDER PHARMACEUTICALS LTD (IN) | 2010-07-22 | — | — | WO | disclosed |