SCHEMBL9911664

SCHEMBL9911664

O=C1S/C(=C/c2ccccc2)C(=O)N1c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 7/20 0.62
KMT2A Q03164 7/20 0.62
NPC1 O15118 6/20 0.62
RAB9A P51151 6/20 0.62
ALDH1A1 P00352 5/20 0.62
SMN1; SMN2 Q16637 2/20 0.62
THRB P10828 1/20 0.62
S1PR1 P21453 3/20 0.61
S1PR3 Q99500 3/20 0.61
DUSP22 Q9NRW4 4/20 0.56
CFTR P13569 1/20 0.53
DUSP3 P51452 1/20 0.52
KDM4E B2RXH2 2/20 0.52
MAPT P10636 2/20 0.52
HTT P42858 2/20 0.52
CISD1 Q9NZ45 2/20 0.51
MAOA P21397 2/20 0.51
MAOB P27338 2/20 0.51
POLB P06746 2/20 0.51
LMNA P02545 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17302124 0.87 THRB (0.81) MEN1KMT2ANPC1RAB9AALDH1A1
SCHEMBL9917038 0.83 DUSP22 (0.77) MEN1KMT2AALDH1A1THRBDUSP22
SCHEMBL12123516 0.83 DUSP22 (0.77) MEN1KMT2AALDH1A1THRBDUSP22
SCHEMBL10035996 0.83 DUSP22 (0.77) MEN1KMT2AALDH1A1THRBDUSP22
SCHEMBL2987796 0.81 MEN1 (0.77) MEN1KMT2ANPC1RAB9AALDH1A1
SCHEMBL17295555 0.80 S1PR3 (0.73) MEN1KMT2AALDH1A1THRBS1PR1
SCHEMBL17295556 0.80 S1PR3 (0.73) MEN1KMT2AALDH1A1THRBS1PR1
SCHEMBL2985626 0.79 MEN1 (0.76) MEN1KMT2ANPC1RAB9AALDH1A1
SCHEMBL17309290 0.79 MEN1 (0.79) MEN1KMT2AALDH1A1SMN1; SMN2S1PR1
SCHEMBL12013235 0.79 MEN1 (0.79) MEN1KMT2AALDH1A1SMN1; SMN2S1PR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140364467-A1 CHEMICAL INDUCERS OF NEUROGENESIS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2014-12-11 US disclosed
US-20140364467-A1 CHEMICAL INDUCERS OF NEUROGENESIS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2014-12-11 US disclosed
US-8778940-B2 Chemical inducers of neurogenesis THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2014-07-15 US disclosed
US-8778940-B2 Chemical inducers of neurogenesis THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2014-07-15 US disclosed
US-20130143935-A1 STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2013-06-06 US disclosed
US-20130143935-A1 STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2013-06-06 US disclosed
US-20130143885-A1 CHEMICAL INDUCERS OF NEUROGENESIS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2013-06-06 US disclosed
US-20130143885-A1 CHEMICAL INDUCERS OF NEUROGENESIS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2013-06-06 US disclosed
US-8193225-B2 Isoxazole amides, derivatives and methods of chemical induction of neurogenesis THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2012-06-05 US disclosed
US-8193225-B2 Isoxazole amides, derivatives and methods of chemical induction of neurogenesis THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2012-06-05 US disclosed
US-20120029200-A1 Stem Cell Differentiating Agents and Uses Therefor NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2012-02-02 US disclosed
US-20120029200-A1 Stem Cell Differentiating Agents and Uses Therefor NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2012-02-02 US disclosed
US-7981935-B2 Stem cell differentiating agents and uses therefor THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2011-07-19 US disclosed
US-7981935-B2 Stem cell differentiating agents and uses therefor THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2011-07-19 US disclosed
WO-2009038879-A2 STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2009-03-26 WO disclosed
US-20090076103-A1 STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2009-03-19 US disclosed
US-20090076103-A1 STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2009-03-19 US disclosed
US-20090036451-A1 Chemical inducers of neurogenesis THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2009-02-05 US disclosed
US-20090036451-A1 Chemical inducers of neurogenesis THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2009-02-05 US disclosed
WO-2008046072-A2 CHEMICAL INDUCERS OF NEUROGENESIS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2008-04-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120029200-A1 Stem Cell Differentiating Agents and Uses Therefor MYADM, MCL1, NOTCH4 MEN1 3309/4885KMT2A 1982/4885NPC1 1970/4885
US-20090076103-A1 STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR MYADM, MCL1, NOTCH4 MEN1 3309/4885KMT2A 1982/4885NPC1 1970/4885
US-20140364467-A1 CHEMICAL INDUCERS OF NEUROGENESIS DCX, NES, GAP43 MEN1 3223/4885KMT2A 1862/4885NPC1 1941/4885
US-20090036451-A1 Chemical inducers of neurogenesis DCX, NES, GAP43 MEN1 3223/4885KMT2A 1862/4885NPC1 1941/4885
US-20130143935-A1 STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR MYADM, MCL1, NOTCH4 MEN1 3309/4885KMT2A 1982/4885NPC1 1970/4885
US-20130143885-A1 CHEMICAL INDUCERS OF NEUROGENESIS DCX, NES, GAP43 MEN1 3223/4885KMT2A 1862/4885NPC1 1941/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.