Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 19/20 | 0.66 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3787953 | 0.82 | TRPM8 (0.46) | TRPM8TRPV1 | |
| SCHEMBL13188844 | 0.79 | TRPM8 (1.00) | TRPM8TRPV1 | |
| SCHEMBL13188834 | 0.78 | TRPM8 (0.74) | TRPM8TRPV1 | |
| SCHEMBL13189138 | 0.77 | TRPM8 (0.80) | TRPM8TRPV1 | |
| SCHEMBL13188901 | 0.73 | TRPM8 (1.00) | TRPM8TRPV1 | |
| SCHEMBL3814047 | 0.73 | TRPM8 (1.00) | TRPM8TRPV1 | |
| SCHEMBL3789581 | 0.72 | TRPM8 (0.53) | TRPM8TRPV1 | |
| SCHEMBL13189135 | 0.69 | TRPM8 (0.75) | TRPM8TRPV1 | |
| SCHEMBL13188827 | 0.69 | TRPM8 (1.00) | TRPM8TRPV1 | |
| SCHEMBL13188131 | 0.69 | TRPM8 (1.00) | TRPM8TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010103381-A1 | SPIROCYCLIC PIPERIDINE DERIVATIVES AS TRPM 8 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-09-16 | — | — | WO | disclosed |