Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 13/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | LCAT | P04180 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3796860 | 0.88 | TRPM8 (0.53) | TRPM8TRPV1HSD11B1SCDLCAT | |
| SCHEMBL3787953 | 0.86 | TRPM8 (0.46) | TRPM8TRPV1SCDHTR2B | |
| SCHEMBL3794698 | 0.74 | TRPM8 (0.70) | TRPM8TRPV1HSD11B1CHRM4 | |
| SCHEMBL3787376 | 0.72 | TRPM8 (0.66) | TRPM8TRPV1 | |
| SCHEMBL3785408 | 0.71 | TRPM8 (0.50) | TRPM8TRPV1HTR2B | |
| SCHEMBL13188844 | 0.69 | TRPM8 (1.00) | TRPM8TRPV1 | |
| SCHEMBL3803441 | 0.68 | TRPM8 (0.55) | TRPM8TRPV1HSD11B1SCD | |
| SCHEMBL3792393 | 0.68 | NPC1 (0.47) | TRPM8TRPV1SCD | |
| SCHEMBL13189138 | 0.68 | TRPM8 (0.80) | TRPM8TRPV1 | |
| SCHEMBL3789378 | 0.67 | TRPM8 (0.54) | TRPM8TRPV1SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010103381-A1 | SPIROCYCLIC PIPERIDINE DERIVATIVES AS TRPM 8 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-09-16 | — | — | WO | claimed |