Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 12/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.46 |
| ▸ | SCD | O00767 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3789581 | 0.86 | TRPM8 (0.53) | TRPM8TRPV1SCDHTR2B | |
| SCHEMBL3787376 | 0.82 | TRPM8 (0.66) | TRPM8TRPV1 | |
| SCHEMBL3796860 | 0.74 | TRPM8 (0.53) | TRPM8TRPV1SCD | |
| SCHEMBL3792393 | 0.69 | NPC1 (0.47) | TRPM8TRPV1SCD | |
| SCHEMBL3785408 | 0.67 | TRPM8 (0.50) | TRPM8TRPV1HTR2B | |
| SCHEMBL3794698 | 0.65 | TRPM8 (0.70) | TRPM8TRPV1 | |
| SCHEMBL3803441 | 0.63 | TRPM8 (0.55) | TRPM8TRPV1SCD | |
| SCHEMBL13188844 | 0.62 | TRPM8 (1.00) | TRPM8TRPV1 | |
| SCHEMBL16314494 | 0.62 | TRPM8 (0.53) | TRPM8TRPV1SCD | |
| SCHEMBL3789378 | 0.62 | TRPM8 (0.54) | TRPM8TRPV1SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010103381-A1 | SPIROCYCLIC PIPERIDINE DERIVATIVES AS TRPM 8 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-09-16 | — | — | WO | disclosed |