SCHEMBL378750

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL17072101	0.90	ESR1 (0.56)	ESR1ABL1ABCB1BCRIGF1R
	SCHEMBL17072098	0.82	ESR1 (0.56)	ESR1ABL1ABCB1BCRIGF1R
	SCHEMBL17072086	0.82	ESR1 (0.56)	ESR1ABL1ABCB1BCRIGF1R
	SCHEMBL29072264	0.81	PTGS2 (0.55)	ESR1ABL1ABCB1BCRADRA2A
	SCHEMBL26088590	0.79	CA2 (0.62)	ESR1IGF1RALOX15CA2ESR2
	SCHEMBL1172078	0.79	CA2 (0.68)	ESR1IGF1RALOX15CA2ESR2
	SCHEMBL2759001	0.78	CA2 (0.45)	IGF1RALOX15CA2CYP3A4PTGS2
	SCHEMBL1070427	0.77	ESR1 (0.65)	ESR1IGF1RALOX15CA2ESR2
	SCHEMBL10405809	0.77	ESR1 (0.65)	ESR1IGF1RALOX15CA2ESR2
	SCHEMBL11228648	0.77	ESR1 (0.65)	ESR1IGF1RALOX15CA2ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.