Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.46 |
| ▸ | ACP1 | P24666 | 2/20 | 0.46 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.44 |
| ▸ | LATS1 | O95835 | 1/20 | 0.44 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 5/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3793746 | 0.78 | ADORA1 (0.35) | HTR2CMERTKADORA1LMNAKMT2A | |
| SCHEMBL3785163 | 0.78 | KCNH3 (0.40) | ACP1LATS1LATS2MAPK8MAPK9 | |
| SCHEMBL3787718 | 0.75 | MEN1 (0.46) | HDAC1KDM4ELMNAHTTKMT2A | |
| SCHEMBL3782842 | 0.75 | ALDH1A1 (0.51) | LMNAKMT2A | |
| SCHEMBL3782854 | 0.75 | NPSR1 (0.39) | PDE5AACP1HTR2AHTR2CMAPK8 | |
| SCHEMBL3784367 | 0.74 | USP2 (0.51) | LATS1MAPK8MAPK9ADORA1KDM4E | |
| SCHEMBL3783305 | 0.72 | MEN1 (0.49) | PDE5AHTR2AHTR2CMAPK14GBA1 | |
| SCHEMBL3789583 | 0.71 | MERTK (0.49) | ACP1LATS1LATS2MERTKLMNA | |
| SCHEMBL3710467 | 0.71 | EGFR (0.46) | HTR2AHTR2CMAPK8MAPK9ADORA3 | |
| SCHEMBL3784230 | 0.71 | ALOX5 (0.42) | HTR2AHTR2CADORA3ALOX5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |