Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 14/20 | 0.49 |
| ▸ | AXL | P30530 | 8/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 6/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | LATS1 | O95835 | 1/20 | 0.40 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3782842 | 0.88 | ALDH1A1 (0.51) | MEN1USP2ALDH1A1LMNACYP1A2 | |
| SCHEMBL3787718 | 0.83 | MEN1 (0.46) | KCNH3MEN1USP2ALDH1A1LMNA | |
| SCHEMBL3793746 | 0.81 | ADORA1 (0.35) | MERTKMEN1USP2ALDH1A1LMNA | |
| SCHEMBL3783305 | 0.80 | MEN1 (0.49) | KCNH3MEN1USP2ALDH1A1LMNA | |
| SCHEMBL3785163 | 0.78 | KCNH3 (0.40) | KCNH3ACP1LATS1LATS2MEN1 | |
| SCHEMBL3713217 | 0.77 | KCNH3 (0.41) | MERTKAXLTYRO3FLT3KCNH3 | |
| SCHEMBL3706380 | 0.76 | KCNH3 (0.42) | MERTKAXLKCNH3ACP1 | |
| SCHEMBL3781754 | 0.74 | PTGS2 (0.46) | MEN1ALDH1A1LMNACYP1A2KMT2A | |
| SCHEMBL3784367 | 0.74 | USP2 (0.51) | AXLFLT3KCNH3LATS1MEN1 | |
| SCHEMBL13286144 | 0.73 | PTGS2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | claimed |
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |