⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451050 | 0.83 | — | — | |
| SCHEMBL4511232 | 0.81 | — | — | |
| SCHEMBL1012929 | 0.81 | — | — | |
| SCHEMBL19350346 | 0.79 | — | — | |
| SCHEMBL3994333 | 0.79 | — | — | |
| SCHEMBL4383929 | 0.79 | PKM (0.58) | — | |
| SCHEMBL21413354 | 0.75 | FFAR2 (0.61) | — | |
| SCHEMBL4383925 | 0.75 | PKM (0.43) | — | |
| SCHEMBL2826865 | 0.75 | ALOX15 (0.41) | — | |
| SCHEMBL2661353 | 0.75 | PKM (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115109049-A | Triazine compound containing aryl urea structure and application thereof | 江西科技师范大学 | 2022-09-27 | — | — | CN | claimed |
| JP-4555547-B2 | — | — | 2010-10-06 | — | — | JP | claimed |
| JP-2004505977-A | — | — | 2004-02-26 | — | — | JP | claimed |
| EP-1320531-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-06-25 | — | — | EP | claimed |
| WO-2002012242-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2002-02-14 | — | — | WO | claimed |
| CN-115109049-B | Triazine compound containing aryl urea structure and application thereof | 江西科技师范大学 | 2023-08-15 | — | — | CN | disclosed |
| CN-115109049-A | Triazine compound containing aryl urea structure and application thereof | 江西科技师范大学 | 2022-09-27 | — | — | CN | disclosed |
| WO-2022159835-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2022-07-28 | — | — | WO | disclosed |
| US-8202899-B2 | Pyrazole urea derivatives used as kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2012-06-19 | — | — | US | disclosed |
| EP-1981851-B1 | KINASE INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2012-01-25 | — | — | EP | disclosed |
| US-8044083-B2 | Kinase inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2011-10-25 | — | — | US | disclosed |
| US-8039639-B2 | Kinase inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2011-10-18 | — | — | US | disclosed |
| WO-2007089646-A1 | KINASE INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-08-09 | — | — | WO | disclosed |
| EP-1202734-B1 | 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PFIZER ITALIA SRL (IT) | 2007-05-02 | — | — | EP | disclosed |
| EP-1778686-A2 | TRIAZOLOPYRIDINYLSULFANYL DERIVATIVES AS P38 MAP KINASE INHIBITORS | Pfizer Limited (GB) | 2007-05-02 | — | — | EP | disclosed |
| CN-1273466-C | Quinoline derivatives and quinazoline derivatives having azolyl group | KIRIN BREWERY (JP) | 2006-09-06 | — | — | CN | disclosed |
| WO-2006018718-A2 | TRIAZOLOPYRIDINYLSULFANYL DERIVATIVES AS P38 MAP KINASE INHIBITORS | PFIZER LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |
| CN-1543459-A | Quinoline derivative and quinazoline derivative having azolyl group | ������������ʽ���� | 2004-11-03 | — | — | CN | disclosed |
| EP-1320531-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002012242-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2002-02-14 | — | — | WO | disclosed |