Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 7/20 | 0.53 |
| ▸ | WNT3A | P56704 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3787786 | 0.81 | TAS1R3 (0.61) | CTNNB1WNT3ASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL8317337 | 0.75 | CTNNB1 (0.56) | CTNNB1WNT3ATAS1R3TAS1R1NPC1 | |
| SCHEMBL3787714 | 0.73 | HPGD (0.54) | CTNNB1WNT3ASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL671055 | 0.73 | CTNNB1 (0.57) | CTNNB1WNT3ASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL28860886 | 0.73 | CTNNB1 (0.60) | CTNNB1WNT3ATAS1R3TAS1R1NPC1 | |
| SCHEMBL26115654 | 0.71 | KDM4E (0.68) | CTNNB1WNT3ATAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL3062497 | 0.70 | NOS3 (0.51) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL3788071 | 0.70 | TAAR1 (0.58) | CTNNB1WNT3ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL11239661 | 0.70 | CTNNB1 (0.63) | CTNNB1WNT3ATAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL15968767 | 0.70 | CTNNB1 (1.00) | CTNNB1WNT3ASMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234486-A1 | BENZIMIDAZOLES AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079011-A1 | BENZIMIDAZOLES AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-06-25 | — | — | WO | disclosed |