Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ribose (Furanose) SCHEMBL17477040 | 1.00 | KDM4E (0.45) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL66295 | 0.77 | PSMB8 (0.59) | KDM4ELMNAMAPTSMN1; SMN2NFKB1 | |
| SCHEMBL8853010 | 0.74 | KDM4E (0.51) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL6008963 | 0.72 | KDM4E (0.55) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL8367682 | 0.72 | KDM4E (0.55) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL8371823 | 0.72 | KDM4E (0.55) | KDM4EGMNNLMNAMAPTBLM | |
| B-D-Galactose SCHEMBL9493917 | 0.72 | ALDH1A1 (0.48) | SLC5A2 | |
| B-D-Galactose SCHEMBL27938149 | 0.71 | SLC5A2 (0.47) | SLC5A2 | |
| B-D-Galactose SCHEMBL27864238 | 0.69 | KDM4E (0.44) | KDM4ESLC5A2 | |
| Ribose (Furanose) SCHEMBL5139187 | 0.69 | PYGL (0.47) | SLC5A2PYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016019096-A1 | INHIBITION OF HSV-1-ASSOCIATED CORNEAL NEOVASCULARIZATION USING INHIBITORS OF CYCLIN-DEPENDENT KINASE 9 | XAVIER UNIVERSITY OF LOUISIANA (US) | 2016-02-04 | — | — | WO | claimed |
| WO-2016019096-A1 | INHIBITION OF HSV-1-ASSOCIATED CORNEAL NEOVASCULARIZATION USING INHIBITORS OF CYCLIN-DEPENDENT KINASE 9 | XAVIER UNIVERSITY OF LOUISIANA (US) | 2016-02-04 | — | — | WO | disclosed |
| US-20150359854-A1 | INSULIN RECEPTOR INDUCED ELASTIN PRODUCTION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2015-12-17 | — | — | US | disclosed |
| US-9006170-B2 | Compositions for elastogenesis and connective tissue treatment | HUMAN MATRIX SCIENCES, LLC (US) | 2015-04-14 | — | — | US | disclosed |
| US-20130184199-A1 | INSULIN RECEPTOR INDUCED ELASTIN PRODUCTION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2013-07-18 | — | — | US | disclosed |
| EP-1725245-B1 | MANGANESE AND IRON BASED COMPOUNDS FOR ELASTOGENESIS AND CONNECTIVE TISSUE TREATMENT | HUMAN MATRIX SCIENCES LLC (US) | 2012-01-25 | — | — | EP | disclosed |
| US-20100247454-A1 | COMPOSITIONS FOR ELASTOGENESIS AND CONNECTIVE TISSUE TREATMENT | NULASTIN, INC. | 2010-09-30 | — | — | US | disclosed |
| US-7666829-B2 | contains manganese chloride, manganese sulfate or manganese nitrate and ferric ammonium citrate or ferric chloride, for treating skin disorders; stimulating production of insoluble elastin, or deposition of collagen, fibroblasts; improve the appearance of scar; wrinkle resistance | HUMAN MATRIX SCIENCES, LLC (US) | 2010-02-23 | — | — | US | disclosed |
| WO-2009036573-A1 | APPARATUS AND METHOD FOR MONITORING CELL BEHAVIOUR | INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL (CA) | 2009-03-26 | — | — | WO | disclosed |
| EP-1725245-A2 | MANGANESE AND IRON BASED COMPOUNDS FOR ELASTOGENESIS AND CONNECTIVE TISSUE TREATMENT | Human Matrix Sciences, LLC (US) | 2006-11-29 | — | — | EP | disclosed |
| US-20050208150-A1 | Compositions for elastrogenesis and connective tissue treatment | NULASTIN, INC. | 2005-09-22 | — | — | US | disclosed |
| WO-2005082386-A2 | MANGANESE AND IRON BASED COMPOUNDS FOR ELASTOGENESIS AND CONNECTIVE TISSUE TREATMENT | HUMAN MATRIX SCIENCES, LLC (US) | 2005-09-09 | — | — | WO | disclosed |