Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 6/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 3/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713217 | 0.90 | KCNH3 (0.41) | KCNH3CNR2MERTKAXLPTGS1 | |
| SCHEMBL3781206 | 0.89 | CNR2 (0.36) | CNR2 | |
| SCHEMBL3788039 | 0.85 | MAPT (0.44) | KCNH3CNR2 | |
| SCHEMBL3785711 | 0.82 | KCNH3 (0.43) | KCNH3 | |
| SCHEMBL3782999 | 0.79 | KCNH3 (0.41) | KCNH3SCN9A | |
| SCHEMBL3779747 | 0.79 | MPO (0.38) | CNR2 | |
| SCHEMBL3776179 | 0.78 | MPO (0.39) | CNR2 | |
| SCHEMBL3787119 | 0.76 | KCNH3 (0.39) | KCNH3 | |
| SCHEMBL3789583 | 0.76 | MERTK (0.49) | KCNH3MERTKAXLACP1 | |
| SCHEMBL3782046 | 0.74 | MPO (0.45) | KCNH3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | claimed |
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |