Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13258566 | 0.88 | ROCK2 (0.54) | ROCK2ROCK1POLBNAMPTMAPT | |
| SCHEMBL3794734 | 0.87 | ROCK2 (0.53) | ROCK2ROCK1POLBNAMPTMAPT | |
| SCHEMBL3788935 | 0.82 | EPHX2 (0.47) | ROCK2ROCK1EPHX2HDAC1 | |
| SCHEMBL3793750 | 0.77 | ROCK2 (0.57) | ROCK2ROCK1POLBNAMPTMAPT | |
| SCHEMBL3790889 | 0.71 | PPARG (0.52) | ROCK2ROCK1EPHX2HPGDHDAC1 | |
| SCHEMBL3791605 | 0.71 | EPHX2 (0.49) | ROCK2ROCK1EPHX2HDAC1 | |
| SCHEMBL3796727 | 0.70 | EPHX2 (0.52) | ROCK2ROCK1EPHX2HDAC1 | |
| SCHEMBL13258052 | 0.69 | EPHX2 (0.49) | ROCK2ROCK1EPHX2HDAC1 | |
| SCHEMBL3788362 | 0.69 | EPHX2 (0.49) | ROCK2ROCK1EPHX2HDAC1 | |
| SCHEMBL3787175 | 0.69 | EPHX2 (0.57) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |