Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 3/20 | 0.37 |
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3788991 | 0.85 | GPR139 (0.37) | GPR139 | |
| SCHEMBL3797563 | 0.75 | NAMPT (0.43) | SCDNAMPTDGAT2HTTEPHX2 | |
| SCHEMBL13258147 | 0.75 | LMNA (0.41) | SCDNAMPTDGAT2HTTMEN1 | |
| SCHEMBL3783283 | 0.71 | KDM4C (0.45) | MEN1KMT2ARAB9APOLBSMN1; SMN2 | |
| SCHEMBL3790116 | 0.71 | EPHX2 (0.47) | EPHX2 | |
| SCHEMBL13257878 | 0.66 | EPHX2 (0.41) | EPHX2MEN1KMT2ADRD2 | |
| SCHEMBL3792366 | 0.65 | EPHX2 (0.49) | EPHX2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3792564 | 0.64 | EPHX2 (0.39) | GPR139EPHX2DRD2BRD4 | |
| Sulfuric Acid SCHEMBL3794696 | 0.63 | EPHX2 (0.38) | NAMPTEPHX2 | |
| SCHEMBL13257863 | 0.62 | AKT1 (0.37) | NAMPTDGAT2GPR139MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |