Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | MELK | Q14680 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13258013 | 0.88 | DRD2 (0.38) | SMN1; SMN2DGAT2DRD2NAMPTAKT1 | |
| SCHEMBL13257863 | 0.87 | AKT1 (0.37) | SMN1; SMN2DGAT2DRD2NAMPTAKT1 | |
| SCHEMBL3797563 | 0.86 | NAMPT (0.43) | LMNARAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL3795447 | 0.78 | AKT1 (0.43) | DRD2NAMPTAKT1MEN1KMT2A | |
| SCHEMBL3790116 | 0.77 | EPHX2 (0.47) | — | |
| SCHEMBL3792265 | 0.75 | SCD (0.37) | RAB9APOLBSMN1; SMN2DGAT2DRD2 | |
| SCHEMBL3783283 | 0.75 | KDM4C (0.45) | LMNARAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL3789293 | 0.75 | NAMPT (0.42) | LMNASMN1; SMN2NAMPTHTTMEN1 | |
| SCHEMBL3794645 | 0.73 | NAMPT (0.42) | LMNASMN1; SMN2DGAT2NAMPTHTT | |
| SCHEMBL13076485 | 0.72 | GRIN1 (0.50) | LMNASMN1; SMN2DGAT2SYKHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |