Florifenine

Florifenine

SCHEMBL379372

O=C(OCCN1CCCC1)c1ccccc1Nc1ccnc2cc(C(F)(F)F)ccc12

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 2/20 0.49
PDE4D Q08499 2/20 0.49
KCNH2 Q12809 2/20 0.49
HTR2A P28223 1/20 0.49
OPRK1 P41145 1/20 0.49
HTR2B P41595 1/20 0.49
SLC6A3 Q01959 1/20 0.49
CYP3A4 P08684 2/20 0.48
MAPK1 P28482 2/20 0.48
HSD17B10 Q99714 2/20 0.48
HPGD P15428 2/20 0.48
CYP1A2 P05177 2/20 0.48
CYP2C9 P11712 2/20 0.48
CYP2C19 P33261 2/20 0.48
KDR P35968 2/20 0.48
KDM4E B2RXH2 1/20 0.48
MLNR O43193 1/20 0.48
ABCB11 O95342 1/20 0.48
ALDH1A1 P00352 1/20 0.48
CHRM2 P08172 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Florifenine SCHEMBL29400044 1.00 SLC6A2 (0.49) SLC6A2PDE4DKCNH2HTR2AOPRK1
SCHEMBL10510799 0.99 RXFP1 (0.49) SLC6A2PDE4DKCNH2HTR2AOPRK1
SCHEMBL10631435 0.99 RXFP1 (0.49) SLC6A2PDE4DKCNH2HTR2AOPRK1
SCHEMBL10509149 0.95 CYP1A2 (0.49) SLC6A2PDE4DKCNH2HTR2AOPRK1
SCHEMBL10510019 0.94 CYP1A2 (0.48) SLC6A2PDE4DKCNH2HTR2AOPRK1
SCHEMBL10626075 0.94 CYP1A2 (0.48) SLC6A2PDE4DKCNH2HTR2AOPRK1
Antrafenine SCHEMBL24297 0.89 HTR4 (0.51) SLC6A2PDE4DKCNH2HTR2AOPRK1
Antrafenine SCHEMBL29623495 0.89 HTR4 (0.51) SLC6A2PDE4DKCNH2HTR2AOPRK1
SCHEMBL10509025 0.86 CYP3A4 (0.64) SLC6A2PDE4DKCNH2CYP3A4MAPK1
SCHEMBL10510990 0.86 CYP3A4 (0.48) SLC6A2PDE4DKCNH2CYP3A4MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 336 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023075715-A1 A PHARMACEUTICAL FORMULATION INCLUDING LEUKOTRIENE RECEPTOR ANTAGONISTS AND/OR LEUKOTRIENE SYNTHESIS INHIBITORS COMBINED WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) VSY BIYOTEKNOLOJI VE ILAC SANAYI ANONIM SIRKETI (TR) 2023-05-04 WO claimed
EP-3998932-A1 ALKALIZATION OF URINARY BLADDER WALL PRIOR TO TREATMENT WITH INTRAVESICAL HEPARIN AND ALKALINIZED LIDOCAINE TO ENHANCE RELIEF OF BLADDER PAIN SYMPTOMS Parsons, C. Lowell (US) 2022-05-25 EP claimed
WO-2021011566-A1 ALKALIZATION OF URINARY BLADDER WALL PRIOR TO TREATMENT WITH INTRAVESICAL HEPARIN AND ALKALINIZED LIDOCAINE TO ENHANCE RELIEF OF BLADDER PAIN SYMPTOMS PARSONS C LOWELL (US) 2021-01-21 WO claimed
EP-3609483-A1 ARTICLE OF MANUFACTURE COMPRISING LOCAL ANESTHETIC, BUFFER, AND GLYCOSAMINOGLYCAN IN SYRINGE WITH IMPROVED STABILITY Urigen Pharmaceuticals, Inc. (US) 2020-02-19 EP claimed
WO-2018191412-A9 ARTICLE OF MANUFACTURE COMPRISING LOCAL ANESTHETIC, BUFFER, AND GLYCOSAMINOGLYCAN IN SYRINGE WITH IMPROVED STABILITY URIGEN PHARMACEUTICALS, INC. (US) 2019-05-31 WO claimed
WO-2018191412-A1 ARTICLE OF MANUFACTURE COMPRISING LOCAL ANESTHETIC, BUFFER, AND GLYCOSAMINOGLYCAN IN SYRINGE WITH IMPROVED STABILITY URIGEN PHARMACEUTICALS, INC. (US) 2018-10-18 WO claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
WO-2012112690-A2 TARGETING OF THERAPEUTIC DRUGS AND DIAGNOSTIC AGENTS EMPLOYING COLLAGEN BINDING DOMAINS FABIUS BIOTECHNOLOGY (US) 2012-08-23 WO claimed
US-20120183600-A1 NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS CHEN CHIEN-HUNG (US) 2012-07-19 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-20060024365-A1 Novel dosage form VAYA NAVIN 2006-02-02 US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20260034059-A1 ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES AQUESTIVE THERAPEUTICS, INC. (US) 2026-02-05 US disclosed
EP-0094065-A2 2-Aminobenzoic acid derivatives, a process for their preparation and pharmaceutical compositions FERRER INTERNACIONAL, S.A. (ES) 1983-11-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260034059-A1 ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES SORD, SLC6A13, CACNA1A SLC6A2 286/4885PDE4D 1590/4885KCNH2 511/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.