Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.65 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.57 |
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.52 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27884 | 0.88 | LTA4H (0.81) | LTA4HIDO1SAE1UBA2ALDH1A1 | |
| SCHEMBL1425001 | 0.88 | LTA4H (0.81) | LTA4HIDO1SAE1UBA2ALDH1A1 | |
| SCHEMBL7474018 | 0.86 | KDM4E (0.60) | NFE2L2IDO1MAPK1KDM4EMEN1 | |
| Ammonia Solution, Strong SCHEMBL20919857 | 0.85 | LTA4H (0.77) | LTA4HIDO1SAE1UBA2ALDH1A1 | |
| SCHEMBL8298 | 0.85 | — | — | |
| SCHEMBL7024215 | 0.85 | — | — | |
| SCHEMBL24321390 | 0.81 | LTA4H (0.71) | LTA4HIDO1SAE1UBA2MEN1 | |
| SCHEMBL22451382 | 0.81 | LTA4H (0.71) | LTA4HIDO1SAE1UBA2MAOB | |
| SCHEMBL6059611 | 0.81 | LTA4H (0.71) | LTA4HIDO1SAE1UBA2MAOB | |
| SCHEMBL9235879 | 0.81 | LTA4H (0.71) | LTA4HIDO1SAE1UBA2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111548269-A | Preparation method of diarylmethane structure compound | 兰州大学 | 2020-08-18 | — | — | CN | disclosed |
| US-20180186754-A1 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | UMICORE AG & CO. KG (DE) | 2018-07-05 | — | — | US | disclosed |
| US-9890125-B2 | Syntheses of N-heterocyclic carbenes and intermediates therefor | UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2018-02-13 | — | — | US | disclosed |
| US-20170152231-A9 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | UMICORE AG & CO. KG (DE) | 2017-06-01 | — | — | US | disclosed |
| US-20150361049-A1 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | UNIV ST ANDREWS (GB) | 2015-12-17 | — | — | US | disclosed |
| US-20140301999-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | DECODE GENETICS EHF (IS) | 2014-10-09 | — | — | US | disclosed |
| US-20140301999-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | DECODE GENETICS EHF (IS) | 2014-10-09 | — | — | US | disclosed |
| US-20140301999-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | DECODE GENETICS EHF (IS) | 2014-10-09 | — | — | US | disclosed |
| EP-2780326-A1 | METHOD FOR INHIBITION OF DEUBIQUITINATING ACTIVITY | Vivolux Ab (SE) | 2014-09-24 | — | — | EP | disclosed |
| US-8791267-B2 | Biaryl PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders | DECODE GENETICS EHF (IS) | 2014-07-29 | — | — | US | disclosed |
| US-20100068695-A1 | Inhibitor for enzyme having two divalent metal ions as active center | KIYAMA RYUICHI | 2010-03-18 | — | — | US | disclosed |
| US-20100068695-A1 | Inhibitor for enzyme having two divalent metal ions as active center | KIYAMA RYUICHI | 2010-03-18 | — | — | US | disclosed |
| US-20090324569-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | DECODE GENETICS EHF (IS) | 2009-12-31 | — | — | US | disclosed |
| US-20090324569-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | DECODE GENETICS EHF (IS) | 2009-12-31 | — | — | US | disclosed |
| US-20090324569-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | DECODE GENETICS EHF (IS) | 2009-12-31 | — | — | US | disclosed |
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |
| US-6951918-B2 | Peptidic procollagen C-proteinase inhibitors | SYNTEX (U.S.A.) LLC (US) | 2005-10-04 | — | — | US | disclosed |
| US-6242654-B1 | REACTING A PHENOLATE COMPOUND WITH AN ORGANIC FLUORINATING AGENT TO PREPARE A FLUORINE SUBSTITUTED AROMATIC COMPOUND | MITSUI CHEMICALS, INC. (JP) | 2001-06-05 | — | — | US | disclosed |
| EP-1013629-A1 | Preparation process of fluorine subsituted aromatic compound | Mitsui Chemicals, Inc. (JP) | 2000-06-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152231-A9 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | GRHPR, DDC, WEE2 | LTA4H 1487/4885NFE2L2 323/4885IDO1 145/4885 |
| US-20140301999-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | PDE4A, PDE4B, PDE3B | LTA4H 264/4885NFE2L2 1573/4885IDO1 189/4885 |
| US-20180186754-A1 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | GRHPR, DDC, NDC1 | LTA4H 1143/4885NFE2L2 314/4885IDO1 175/4885 |
| US-20150361049-A1 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | GRHPR, DDC, WEE2 | LTA4H 1487/4885NFE2L2 323/4885IDO1 145/4885 |
| US-20090324569-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | PDE4A, PDE4B, PDE3B | LTA4H 264/4885NFE2L2 1573/4885IDO1 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.