Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | PNMT | P11086 | 2/20 | 0.46 |
| ▸ | CD44 | P16070 | 1/20 | 0.40 |
| ▸ | ESRRA | P11474 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794507 | 0.79 | RXRA (0.41) | CD44MRGPRX4P2RY1 | |
| SCHEMBL2857359 | 0.73 | HTR6 (0.52) | DRD2DRD3PNMTCD44MRGPRX4 | |
| Hydrochloric Acid SCHEMBL3798819 | 0.72 | HTR6 (0.51) | DRD2DRD3PNMTCD44MRGPRX4 | |
| SCHEMBL8319663 | 0.71 | CD44 (0.53) | PNMTCD44P2RY1HTR1A | |
| SCHEMBL16518138 | 0.71 | PRCP (0.50) | DRD2DRD3PNMTCD274 | |
| SCHEMBL31233660 | 0.71 | PNMT (0.56) | DRD2DRD3PNMTCD44CD274 | |
| SCHEMBL2358135 | 0.71 | PNMT (0.56) | DRD2DRD3PNMTCD44CD274 | |
| SCHEMBL7645609 | 0.70 | PNMT (0.53) | DRD2DRD3PNMTCD44 | |
| Hydrochloric Acid SCHEMBL33527957 | 0.70 | PNMT (0.55) | DRD2DRD3PNMTCD44CD274 | |
| Hydrochloric Acid SCHEMBL1124611 | 0.70 | PNMT (0.55) | DRD2DRD3PNMTCD44CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010108059-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF THE HISTAMINE H4 RECEPTOR | INCYTE CORPORATION (US) | 2010-09-23 | — | — | WO | claimed |