SCHEMBL379584

SCHEMBL379584

C=CCP.O=S(=O)(O)c1ccccc1

nearest known ligand 0.64

Known targets — ChEMBL curated mechanism

BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.64
SMN1; SMN2 Q16637 2/20 0.64
TDP1 Q9NUW8 3/20 0.48
POLB P06746 1/20 0.46
CYP2D6 P10635 1/20 0.46
LMNA P02545 2/20 0.40
HTR6 P50406 1/20 0.39
ALDH1A1 P00352 7/20 0.39
NT5E P21589 1/20 0.39
PSIP1 O75475 1/20 0.39
HSD17B10 Q99714 3/20 0.38
NAPRT Q6XQN6 1/20 0.38
ESR1 P03372 1/20 0.38
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
TLR9 Q9NR96 1/20 0.38
MMP1 P03956 1/20 0.38
MMP2 P08253 1/20 0.38
MMP9 P14780 1/20 0.38
MMP8 P22894 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Allyl Alcohol SCHEMBL27867941 0.86 SMN1; SMN2 (0.67) TSHRSMN1; SMN2TDP1POLBCYP2D6
SCHEMBL27305425 0.86 TSHR (0.67) TSHRSMN1; SMN2TDP1POLBCYP2D6
SCHEMBL2839261 0.84 TSHR (0.64) TSHRSMN1; SMN2TDP1POLBCYP2D6
SCHEMBL9491969 0.84 TSHR (0.64) TSHRSMN1; SMN2TDP1POLBCYP2D6
Allylamine SCHEMBL11208723 0.84 TSHR (0.64) TSHRSMN1; SMN2TDP1POLBCYP2D6
Butadiene SCHEMBL21933110 0.83 TSHR (0.76) TSHRSMN1; SMN2TDP1POLBCYP2D6
Propene SCHEMBL436529 0.81 TSHR (0.73) TSHRSMN1; SMN2TDP1POLBCYP2D6
Propene SCHEMBL6243344 0.81 TSHR (0.73) TSHRSMN1; SMN2TDP1POLBCYP2D6
SCHEMBL30955955 0.81 TSHR (0.73) TSHRSMN1; SMN2TDP1POLBCYP2D6
SCHEMBL28810412 0.81 TSHR (0.73) TSHRSMN1; SMN2TDP1POLBCYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8178702-B2 Composition, method of authenticating, methods of making authenticatable compositions, authenticatable articles made there from SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-05-15 US disclosed
EP-1325498-B1 COLORED DATA STORAGE MEDIA SABIC INNOVATIVE PLASTICS IP (NL) 2012-01-25 EP disclosed
EP-1954764-B1 BENZOPYRAN COLORANTS, METHOD OF MANUFACTURE, AND METHOD OF USE SABIC INNOVATIVE PLASTICS IP (NL) 2010-12-22 EP disclosed
US-RE41616-E1 Tagging materials for polymers, methods, and articles made thereby SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2010-08-31 US disclosed
US-7645884-B2 Chemical compositions for authenticatable polymers and articles, and authentication methods thereof SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2010-01-12 US disclosed
EP-1461853-B1 COLORED DVD SABIC INNOVATIVE PLASTICS IP (NL) 2009-12-30 EP disclosed
US-7635778-B2 For example, 3-ethylcarbonate-2-(4-(3-ethylcarbonate-4-oxo-4H-chromen-2-yl)phenyl)-4H-chromen-4-one; authentication markers for use in data storage media substrates SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2009-12-22 US disclosed
EP-1692204-B1 IONIZING RADIATION STABLE POLYARYLESTERCARBONATE COMPOSITIONS SABIC INNOVATIVE PLASTICS IP (NL) 2009-06-10 EP disclosed
EP-1820193-B1 METHOD OF AUTHENTICATING TAGGED POLYMERS SABIC INNOVATIVE PLASTICS IP (NL) 2009-04-22 EP disclosed
US-20080265176-A1 COMPOSITION, METHOD OF AUTHENTICATING, METHODS OF MAKING AUTHENTICATABLE COMPOSITIONS, AUTHENTICATABLE ARTICLES MADE THERE FROM SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2008-10-30 US disclosed
US-20030021998-A1 TAGGING MATERIALS FOR POLYMERS, METHODS, AND ARTICLES MADE THEREBY CITIBANK, N.A., AS COLLATERAL AGENT 2003-01-30 US disclosed
WO-2003006965-A1 TAGGING MATERIALS FOR POLYMERS, METHODS, AND ARTICLES MADE THEREBY GENERAL ELECTRIC COMPANY (US) 2003-01-23 WO disclosed
WO-2003005354-A1 VIBRATION DAMPING MONOLITHIC POLYMERS GENERAL ELECTRIC COMPANY (US) 2003-01-16 WO disclosed
US-6475589-B1 Colored optical discs and methods for making the same GENERAL ELECTRIC COMPANY 2002-11-05 US disclosed
US-6475588-B1 COLORED DISK GENERAL ELECTRIC COMPANY 2002-11-05 US disclosed
US-20020094455-A1 Poly(arylene ether) data storage media SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2002-07-18 US disclosed
US-20020072559-A1 Colored data storage media SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2002-06-13 US disclosed
WO-2002029801-A1 COLORED DATA STORAGE MEDIA GENERAL ELECTRIC COMPANY A CORPORATION OF THE STATE OF NEW YORK (US) 2002-04-11 WO disclosed
US-6355766-B1 BLEND OF LOW AND HIGH MOLECULAR WEIGHTS; DIMENSIONAL STABILITY, BIREFRINGENCE; OPTICS GENERAL ELECTRIC COMPANY 2002-03-12 US disclosed
WO-2001083616-A1 POLYCARBONATE COMPOSITIONS FOR DATA STORAGE MEDIA GENERAL ELECTRIC COMPANY (US) 2001-11-08 WO disclosed