Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 5/20 | 0.40 |
| ▸ | PPME1 | Q9Y570 | 3/20 | 0.40 |
| ▸ | APEH | P13798 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29713729 | 0.72 | PPME1 (0.55) | HTR6PPME1APEHMEN1KMT2A | |
| SCHEMBL298398 | 0.72 | CYP2C19 (0.49) | RAPGEF4HTR6MEN1KMT2AL3MBTL1 | |
| SCHEMBL295549 | 0.71 | CYP2C19 (0.48) | RAPGEF4HTR6MEN1KMT2AL3MBTL1 | |
| SCHEMBL1599348 | 0.67 | HTR6 (0.50) | RAPGEF4HTR6PPME1APEHMEN1 | |
| SCHEMBL10466733 | 0.66 | RAPGEF4 (0.76) | RAPGEF4HTR6PPME1APEHMEN1 | |
| SCHEMBL17574711 | 0.65 | MEN1 (0.55) | RAPGEF4HTR6PPME1APEHMEN1 | |
| SCHEMBL10176180 | 0.64 | HTR6 (0.47) | RAPGEF4HTR6PPME1APEHMEN1 | |
| SCHEMBL8349426 | 0.64 | CYP2C19 (0.52) | MEN1KMT2APOLBALDH1A1LMNA | |
| SCHEMBL10467848 | 0.64 | RAPGEF4 (0.58) | RAPGEF4HTR6PPME1APEHMEN1 | |
| SCHEMBL14760380 | 0.63 | HTR6 (0.50) | HTR6PPME1APEHMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |