Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.32 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29427860 | 1.00 | MAPT (0.39) | MAPTGAAALDH1A1HSPA1APTPN7 | |
| SCHEMBL943810 | 0.84 | EGFR (0.32) | MAPTGAAEGFRMAPK1CYP1A2 | |
| SCHEMBL29138002 | 0.80 | ALDH1A1 (0.35) | MAPTALDH1A1EGFRNPC1RAB9A | |
| SCHEMBL28671894 | 0.77 | RECQL (0.36) | MAPTGAAALDH1A1MAPK1NPC1 | |
| SCHEMBL7603455 | 0.75 | EGFR (0.42) | MAPTGAAALDH1A1EGFRMAPK1 | |
| SCHEMBL27988772 | 0.73 | GAA (0.33) | MAPTGAA | |
| SCHEMBL17338036 | 0.70 | L3MBTL1 (0.35) | ALDH1A1MAPK1NPC1 | |
| SCHEMBL1420618 | 0.69 | NOS2 (0.33) | MAPTGAA | |
| SCHEMBL16321015 | 0.69 | GAA (0.30) | MAPTGAA | |
| SCHEMBL28144059 | 0.69 | GAA (0.30) | MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115322157-B | Letermopevir intermediate compound, preparation method and application thereof | 浙江车头制药股份有限公司 | 2023-12-05 | — | — | CN | disclosed |
| CN-115322157-A | Letemovir intermediate compound and preparation method and application thereof | 浙江车头制药股份有限公司 | 2022-11-11 | — | — | CN | disclosed |
| EP-1893587-B1 | METHOD FOR PRODUCING DIHYDROQUINAZOLINES | AICURIS GMBH & CO KG (DE) | 2012-01-25 | — | — | EP | disclosed |
| EP-1893587-A1 | METHOD FOR PRODUCING DIHYDROQUINAZOLINES | Bayer HealthCare AG (DE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133822-A1 | METHOD FOR PRODUCING DIHYDROQUINAZOLINES | BAYER HEALTHCARE AG (DE) | 2006-12-21 | — | — | WO | disclosed |