Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.50 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666588 | 0.93 | SSTR5 (0.42) | SLC6A5DRD4SSTR5PRMT5WDR77 | |
| SCHEMBL649468 | 0.89 | SLC6A5 (0.64) | SLC6A5DRD4SSTR5HIF1AEPAS1 | |
| SCHEMBL3662808 | 0.88 | PRKAA2 (0.46) | SLC6A5SSTR5 | |
| SCHEMBL3798034 | 0.88 | SLC6A5 (0.50) | SLC6A5HIF1AEPAS1KCNH2MCHR1 | |
| SCHEMBL3662664 | 0.86 | SLC6A5 (0.46) | SLC6A5DRD4HIF1AEPAS1KCNH2 | |
| SCHEMBL4441003 | 0.86 | DRD4 (0.43) | SLC6A5DRD4KCNH2DRD2OPRM1 | |
| SCHEMBL3668577 | 0.85 | SLC6A5 (0.45) | SLC6A5DRD4HIF1AEPAS1KCNH2 | |
| SCHEMBL649704 | 0.81 | SSTR5 (0.54) | SLC6A5DRD4SSTR5HIF1AEPAS1 | |
| SCHEMBL3661407 | 0.80 | SLC6A5 (0.42) | SLC6A5DRD4HIF1AEPAS1DRD2 | |
| SCHEMBL3660163 | 0.80 | F10 (0.39) | SLC6A5DRD4KCNH2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |