Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ME2 | P23368 | 8/20 | 0.61 |
| ▸ | ME1 | P48163 | 8/20 | 0.61 |
| ▸ | ME3 | Q16798 | 8/20 | 0.61 |
| ▸ | GAA | P10253 | 7/20 | 0.60 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12206782 | 0.80 | GAA (0.58) | ME2ME1ME3GAAMAPT | |
| SCHEMBL13465510 | 0.78 | GAA (0.56) | ME2ME1ME3GAAMAPT | |
| SCHEMBL14524661 | 0.78 | MAPT (0.67) | ME2ME1ME3GAAMAPT | |
| SCHEMBL10981623 | 0.78 | ME2 (0.64) | ME2ME1ME3GAAMAPT | |
| SCHEMBL3466014 | 0.77 | TDP1 (0.64) | ME2ME1ME3GAAMAPT | |
| SCHEMBL23244396 | 0.76 | ME2 (0.86) | ME2ME1ME3GAAMAPT | |
| SCHEMBL23244223 | 0.76 | ME3 (1.00) | ME2ME1ME3GAAMAPT | |
| SCHEMBL27936730 | 0.75 | TDP1 (0.66) | ME2ME1ME3GAAMAPT | |
| SCHEMBL2312607 | 0.74 | GAA (0.61) | ME2ME1ME3GAAMAPT | |
| SCHEMBL2312088 | 0.74 | GAA (0.61) | ME2ME1ME3GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028776-A1 | PIPERAZINE DERIVATIVES FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-03-18 | — | — | WO | disclosed |