Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.56 |
| ▸ | ME2 | P23368 | 8/20 | 0.51 |
| ▸ | ME1 | P48163 | 8/20 | 0.51 |
| ▸ | ME3 | Q16798 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12206782 | 0.88 | GAA (0.58) | GAAME2ME1ME3MAPT | |
| SCHEMBL3801230 | 0.78 | ME2 (0.61) | GAAME2ME1ME3MAPT | |
| SCHEMBL6905218 | 0.77 | KMT2A (0.60) | ME2ME1ME3MAPTLMNA | |
| SCHEMBL381360 | 0.76 | MAPT (0.68) | GAAME2ME1ME3MAPT | |
| SCHEMBL17590071 | 0.76 | MAPT (0.50) | GAAME2ME1ME3MAPT | |
| SCHEMBL13279526 | 0.73 | MAPT (0.64) | GAAMAPTLMNAKDM4EKMT2A | |
| SCHEMBL2308072 | 0.73 | SIGMAR1 (0.59) | GAAME2ME1ME3MAPT | |
| SCHEMBL14452826 | 0.72 | RAB9A (0.62) | MAPTLMNAKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL13281422 | 0.72 | MAPT (0.62) | GAAMAPTLMNAKDM4EKMT2A | |
| SCHEMBL9396856 | 0.72 | MAPT (0.62) | GAAMAPTLMNAKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028776-A1 | PIPERAZINE DERIVATIVES FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-03-18 | — | — | WO | disclosed |