Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 7/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3800201 | 0.84 | PTGES (0.43) | KMT2AMEN1TP53PTGESNPC1 | |
| SCHEMBL3800584 | 0.82 | PTGES (0.44) | ALOX15KMT2AMEN1TP53PTGES | |
| SCHEMBL2360979 | 0.76 | PTGES (0.43) | ALOX15PTGESJAK2KDM4ETSHR | |
| SCHEMBL13075516 | 0.71 | NPC1 (0.46) | KMT2AMEN1TP53PTGESNPC1 | |
| SCHEMBL4786450 | 0.71 | HDAC1 (0.46) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL3796320 | 0.69 | PTGES (0.49) | PTGESJAK2PIM1CSNK2A2CSNK2B | |
| SCHEMBL22428191 | 0.69 | POLB (0.49) | — | |
| SCHEMBL4786449 | 0.68 | HDAC1 (0.42) | KMT2AMEN1PTGESKDM4ENPSR1 | |
| SCHEMBL13075532 | 0.67 | GCGR (0.40) | PTGESLMNAHPGD | |
| SCHEMBL13075541 | 0.67 | KDM4E (0.43) | PTGESNPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |