Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 16/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786449 | 0.91 | HDAC1 (0.42) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL13075516 | 0.83 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2KDM4EPKM | |
| SCHEMBL13075946 | 0.81 | DEGS1 (0.46) | HDAC6NPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL4783219 | 0.81 | TTR (0.55) | NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4784907 | 0.79 | RHEB (0.46) | NPC1RAB9ASMN1; SMN2KDM4EPKM | |
| SCHEMBL13075541 | 0.77 | KDM4E (0.43) | NPC1RAB9AKDM4E | |
| SCHEMBL4786423 | 0.77 | MEN1 (0.47) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL29662800 | 0.76 | PTGES (0.43) | — | |
| SCHEMBL13076230 | 0.75 | PTGES (0.43) | — | |
| SCHEMBL13075532 | 0.75 | GCGR (0.40) | LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008084218-A1 | BENZAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-07-17 | — | — | WO | disclosed |