Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 14/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | EIF4E | P06730 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14692526 | 0.83 | KMO (0.38) | EIF4EDHODHKMO | |
| SCHEMBL3795491 | 0.82 | PTGES (0.43) | PTGESJAK2TTREIF4EDHODH | |
| SCHEMBL4783219 | 0.79 | TTR (0.55) | PTGESJAK2TTREIF4EDHODH | |
| SCHEMBL4786153 | 0.77 | EIF4E (0.50) | PTGESTTREIF4EDHODHKMO | |
| SCHEMBL28775125 | 0.76 | ALPL (0.44) | PTGESKDM4ETDP1 | |
| SCHEMBL3801465 | 0.76 | ALOX15 (0.36) | PTGESJAK2KDM4EALOX15TSHR | |
| SCHEMBL2574268 | 0.75 | PTGES (0.44) | PTGESJAK2JAK3 | |
| SCHEMBL3800201 | 0.75 | PTGES (0.43) | PTGES | |
| SCHEMBL3800584 | 0.74 | PTGES (0.44) | PTGESALOX15 | |
| SCHEMBL3799835 | 0.74 | PTGES (0.45) | PTGESJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011099832-A2 | NOVEL BENZIMIDAZOLE COMPOUND, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | CRYSTALGENOMICS, INC. (KR) | 2011-08-18 | — | — | WO | disclosed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |