Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 3/20 | 0.44 |
| ▸ | CCND1 | P24385 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3797880 | 0.81 | ALDH1A1 (0.41) | NPC1RAB9AALDH1A1CDK4CCND1 | |
| SCHEMBL3806468 | 0.80 | NPC1 (0.40) | NPC1RAB9AATMALDH1A1PTGS1 | |
| SCHEMBL3800066 | 0.80 | MEN1 (0.40) | NPC1RAB9AALDH1A1CDK4CCND1 | |
| SCHEMBL11670620 | 0.79 | MEN1 (0.60) | MEN1KMT2ALMNANPSR1MAPT | |
| SCHEMBL7585320 | 0.79 | ALDH1A1 (0.52) | NPC1RAB9AATMALDH1A1CDK4 | |
| SCHEMBL3804572 | 0.78 | ALDH1A1 (0.44) | NPC1RAB9AALDH1A1CDK4CCND1 | |
| SCHEMBL3805967 | 0.78 | ALDH1A1 (0.43) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL6394938 | 0.76 | ALDH1A1 (0.56) | NPC1RAB9AALDH1A1CDK4MEN1 | |
| SCHEMBL27474102 | 0.76 | LMNA (0.58) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL9942738 | 0.76 | NR4A2 (0.46) | NPC1RAB9AALDH1A1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167077-A2 | ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR | Bayer Schering Pharma Aktiengesellschaft (DE) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008152099-A2 | ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-12-18 | — | — | WO | disclosed |