Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 4/20 | 0.44 |
| ▸ | CCND1 | P24385 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | FPR1 | P21462 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3800066 | 0.77 | MEN1 (0.40) | NR4A2CDK4CCND1MAPTKDM4E | |
| SCHEMBL3801993 | 0.76 | NPC1 (0.52) | CDK4CCND1MAPTKMT2AMEN1 | |
| SCHEMBL6394938 | 0.74 | ALDH1A1 (0.56) | CDK4MAPTHPGDKDM4ESMN1; SMN2 | |
| SCHEMBL7585320 | 0.74 | ALDH1A1 (0.52) | NR4A2CDK4CCND1MAPTHPGD | |
| SCHEMBL3866597 | 0.74 | OXTR (0.44) | NR4A2MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3797880 | 0.72 | ALDH1A1 (0.41) | CDK4CCND1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL27474102 | 0.71 | LMNA (0.58) | NR4A2MAPTHPGDKDM4ESMN1; SMN2 | |
| SCHEMBL3804572 | 0.71 | ALDH1A1 (0.44) | CDK4CCND1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL3805967 | 0.71 | ALDH1A1 (0.43) | NR4A2MAPTHPGDKDM4ESMN1; SMN2 | |
| SCHEMBL26978217 | 0.70 | ALDH1A1 (0.51) | MAPTHPGDKDM4ESMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651887-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Katholieke Universiteit Leuven K.U. Leuven R&D (BE) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012080220-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-21 | — | — | WO | disclosed |