Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 6/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794424 | 0.90 | PTGES (0.47) | PTGESJAK2HPGDSNPC1CASP3 | |
| SCHEMBL3793690 | 0.86 | PTGES (0.46) | PTGESJAK2HPGDSNPC1CASP3 | |
| SCHEMBL13076382 | 0.86 | HTT (0.42) | PTGESHTTNPC1CASP3RAB9A | |
| SCHEMBL3790517 | 0.85 | PTGES (0.54) | PTGESJAK2HPGDSNPC1CASP3 | |
| SCHEMBL3797347 | 0.81 | PTGES (0.50) | PTGESJAK2HPGDSNPC1RAB9A | |
| SCHEMBL3797930 | 0.81 | PTGES (0.46) | PTGESJAK2HPGDSNPC1CASP3 | |
| SCHEMBL3795318 | 0.80 | PTGES (0.45) | PTGESJAK2HPGDSNPC1CASP3 | |
| SCHEMBL3800503 | 0.80 | PTGES (0.49) | PTGESJAK2HPGDSNPC1RAB9A | |
| SCHEMBL3803620 | 0.80 | PTGES (0.43) | PTGESJAK2HPGDSNPC1RAB9A | |
| SCHEMBL3796009 | 0.79 | PTGES (0.44) | PTGESJAK2HPGDSNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | claimed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |