SCHEMBL38027

SCHEMBL38027

COc1cc[c]nn1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2750090 0.80 ALDH1A1 (0.39)
SCHEMBL745834 0.78
SCHEMBL1482956 0.78
SCHEMBL2752816 0.75 GAA (0.36)
SCHEMBL2753660 0.75 CA2 (0.47)
SCHEMBL9565082 0.74 LMNA (0.35)
SCHEMBL2752954 0.74 CA12 (0.50)
SCHEMBL17074403 0.73
SCHEMBL667974 0.73
SCHEMBL2753697 0.72 TSHR (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 534 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230047816-A1 PFKFB3 INHIBITORS AND THEIR USES GERO PTE. LTD. (SG) 2023-02-16 US claimed
CN-113396145-A PFKFB3 inhibitors and uses thereof 盖罗发现有限责任公司 2021-09-14 CN claimed
WO-2020080979-A1 PFKFB3 INHIBITORS AND THEIR USES GERO DISCOVERY LIMITED LIABILITY COMPANY (RU) 2020-04-23 WO claimed
EP-3538518-A1 SUBSTITUTED QUINOXALINE DERIVATIVES AS INHIBITORS OF PFKFB Merck Patent GmbH (DE) 2019-09-18 EP claimed
US-20190256499-A1 SUBSTITUTED QUINOXALINE DERIVATIVES AS INHIBITORS OF PFKFB MERCK PATENT GMBH (DE) 2019-08-22 US claimed
US-10383874-B2 Arylquinazolines MERK PATENT GMBH (DE) 2019-08-20 US claimed
US-20190142833-A1 ARYLQUINAZOLINES MERCK PATENT GMBH (DE) 2019-05-16 US claimed
US-10172859-B2 Arylquinazolines MERCK PATENT GMBH (DE) 2019-01-08 US claimed
EP-3204377-B1 AMINOPYRIDYLOXYPYRAZOLE COMPOUNDS LILLY CO ELI (US) 2018-09-26 EP claimed
EP-3363788-A1 CANNABINOID RECEPTOR MODULATORS Arena Pharmaceuticals, Inc. (US) 2018-08-22 EP claimed
WO-2001054691-A1 NITRATE SALTS OF ANTIMICROBIAL AGENTS NICOX, S.A. (FR) 2001-08-02 WO claimed
WO-2000023444-A1 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2000-04-27 WO claimed
US-5270308-A Hypotensives TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-12-14 US claimed
US-5264434-A Insecticides, miticides or nematocides BASF AKTIENGESELLSCHAFT (DE) 1993-11-23 US claimed
EP-0233801-B1 SUBSTITUTED AMIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM RHONE POULENC SANTE (FR) 1990-05-23 EP claimed
US-4753941-A HYPNOTICS, MUSCLE RELAXANTS RHONE-POULENC SANTE (FR) 1988-06-28 US claimed
US-4333936-A Novel amidino-benzylpyrimidines, processes for their manufacture and antibacterial and antiprotozoal use thereof BASF AKTIENGESELLSCHAFT (DE) 1982-06-08 US claimed
US-4332796-A MICROCRYSTALS COATED WITH MIXTURES OF PHOSPHOLIPIDS AND NONIONIC SURFACTANTS LABORATORIOS BAGO S.A. (AR) 1982-06-01 US claimed
EP-0000336-B1 N-BENZYLPYRIMIDINYL-AMIDINES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM BASF Aktiengesellschaft (DE) 1981-04-15 EP claimed
EP-0000336-A1 N-benzylpyrimidinyl-amidines, process for their preparation and medicines containing them BASF Aktiengesellschaft (DE) 1979-01-24 EP claimed