SCHEMBL380329

SCHEMBL380329

CCOC([SiH3])(CCCCN(CC)CC)OCC

nearest known ligand 0.42

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 2/20 0.42
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
APOBEC3A P31941 1/20 0.33
APOBEC3G Q9HC16 1/20 0.33
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL379492 0.94 SIGMAR1 (0.36) SIGMAR1CYP3A4CYP2D6APOBEC3AAPOBEC3G
SCHEMBL379573 0.85 SIGMAR1 (0.31) SIGMAR1
SCHEMBL379595 0.82 ALDH1A1 (0.40) SIGMAR1ALDH1A1
SCHEMBL379352 0.82 SIGMAR1 (0.40) SIGMAR1APOBEC3AAPOBEC3GALDH1A1
SCHEMBL10970539 0.77
SCHEMBL379298 0.75 SIGMAR1 (0.33) SIGMAR1APOBEC3AAPOBEC3GALDH1A1
SCHEMBL329401 0.75 ALDH1A1 (0.36) ALDH1A1
SCHEMBL3924179 0.74
SCHEMBL21723155 0.74 TSHR (0.38)
SCHEMBL29124493 0.74 TSHR (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2511334-B1 TYRE RUBBER COMPOSITION AND PNEUMATIC TYRE SUMITOMO RUBBER IND (JP) 2018-04-25 EP disclosed
EP-2174801-B1 Rubber composition and pneumatic tire SUMITOMO RUBBER IND (JP) 2016-10-19 EP disclosed
US-8800621-B2 Rubber composition and tire SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2014-08-12 US disclosed
US-20120283354-A1 TYRE RUBBER COMPOSITION AND PNEUMATIC TYRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2012-11-08 US disclosed
EP-2366558-B1 Tire rubber composition and heavy-load tire SUMITOMO RUBBER IND (JP) 2012-10-31 EP disclosed
EP-2511334-A1 TYRE RUBBER COMPOSITION AND PNEUMATIC TYRE Sumitomo Rubber Industries, Ltd. (JP) 2012-10-17 EP disclosed
EP-2366557-B1 Tire rubber composition and pneumatic tire SUMITOMO RUBBER IND (JP) 2012-05-23 EP disclosed
US-8163821-B2 Tire rubber composition and heavy-load tire SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2012-04-24 US disclosed
EP-2184317-B1 Rubber composition and tire SUMITOMO RUBBER IND (JP) 2012-04-18 EP disclosed
US-8119721-B2 Tread rubber composition for studless tire and studless tire SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2012-02-21 US disclosed
US-20110230613-A1 TIRE RUBBER COMPOSITION AND HEAVY-LOAD TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2011-09-22 US disclosed
US-20110230593-A1 TIRE RUBBER COMPOSITION AND PNEUMATIC TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2011-09-22 US disclosed
EP-2366557-A1 Tire rubber composition and pneumatic tire Sumitomo Rubber Industries, Ltd. (JP) 2011-09-21 EP disclosed
EP-2366558-A1 Tire rubber composition and heavy-load tire Sumitomo Rubber Industries, Ltd. (JP) 2011-09-21 EP disclosed
EP-2196324-A1 Tread rubber composition for studless tire and studless tire Sumitomo Rubber Industries, Ltd. (JP) 2010-06-16 EP disclosed
US-20100144954-A1 TREAD RUBBER COMPOSITION FOR STUDLESS TIRE AND STUDLESS TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2010-06-10 US disclosed
EP-2184317-A1 Rubber composition and tire Sumitomo Rubber Industries, Ltd. (JP) 2010-05-12 EP disclosed
US-20100108213-A1 RUBBER COMPOSITION AND TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2010-05-06 US disclosed
EP-2174801-A2 Rubber composition and pneumatic tire Sumitomo Rubber Industries, Ltd. (JP) 2010-04-14 EP disclosed
US-20100084065-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2010-04-08 US disclosed