Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4944661 | 0.85 | NPSR1 (0.49) | NPSR1ALDH1A1TSHRTDP1GPR35 | |
| SCHEMBL4372849 | 0.80 | NPSR1 (0.55) | NPSR1ALDH1A1TSHRTDP1GPR35 | |
| SCHEMBL8331183 | 0.77 | NPSR1 (0.60) | NPSR1ALDH1A1TSHRTDP1GPR35 | |
| SCHEMBL2956140 | 0.77 | NPSR1 (0.60) | NPSR1ALDH1A1TSHRTDP1GPR35 | |
| SCHEMBL11427505 | 0.77 | NPSR1 (0.51) | NPSR1ALDH1A1TSHRTDP1GPR35 | |
| SCHEMBL7528689 | 0.74 | NPSR1 (0.57) | NPSR1ALDH1A1TSHRTDP1GPR35 | |
| SCHEMBL5180040 | 0.74 | NPSR1 (0.51) | NPSR1ALDH1A1TSHRTDP1GPR35 | |
| SCHEMBL380403 | 0.74 | ALDH1A1 (0.51) | NPSR1ALDH1A1TSHRGPR35MEN1 | |
| SCHEMBL15284094 | 0.73 | NPSR1 (0.59) | NPSR1ALDH1A1TSHRTDP1GPR35 | |
| SCHEMBL1999849 | 0.72 | ALDH1A1 (0.50) | NPSR1ALDH1A1TSHRTDP1GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9168389-B2 | Harmonic generation for activation of species and/or delivery of species to a target environment | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-10-27 | — | — | US | claimed |
| US-20140234938-A1 | HARMONIC GENERATION FOR ACTIVATION OF SPECIES AND/OR DELIVERY OF SPECIES TO A TARGET ENVIRONMENT | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2014-08-21 | — | — | US | claimed |
| US-8246754-B2 | Process for removing ink from printed substrate | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2012-08-21 | — | — | US | claimed |
| US-20210196842-A1 | SITE-SPECIFIC RADIOFLUORINATION OF PEPTIDES WITH 8-[18F]-FLUOROOCTANOIC ACID CATALYZED BY LIPOIC ACID LIGASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-07-01 | — | — | US | disclosed |
| WO-2018005980-A1 | COMPOSITIONS AND DIAGNOSTIC METHODS RELATED TO TRANSTHYRETIN AMYLOID DISEASES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-01-04 | — | — | WO | disclosed |
| WO-2017095806-A1 | SITE-SPECIFIC RADIOFLUORINATION OF PEPTIDES WITH 8-[18F]-FLUOROOCTANOIC ACID CATALYZED BY LIPOIC ACID LIGASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-08 | — | — | WO | disclosed |
| US-9284541-B2 | Methods and compositions for protein labeling using lipoic acid ligases | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2016-03-15 | — | — | US | disclosed |
| US-9168389-B2 | Harmonic generation for activation of species and/or delivery of species to a target environment | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-10-27 | — | — | US | disclosed |
| US-20150125904-A1 | PROBE INCORPORATION MEDIATED BY ENZYMES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-05-07 | — | — | US | disclosed |
| US-8951547-B2 | Drug delivery system | LUMEMED LIMITED (GB) | 2015-02-10 | — | — | US | disclosed |
| US-8871456-B2 | Probe incorporation mediated by enzymes | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-10-28 | — | — | US | disclosed |
| US-8137925-B2 | Methods and compositions for protein labeling using lipoic acid ligases | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-03-20 | — | — | US | disclosed |
| EP-2408783-A2 | BIOMOLECULAR LABELLING USING MULTIFUNCTIONAL BIOTIN ANALOGUES | University Of Nottingham (GB) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010106347-A2 | BIOMOLECULAR LABELLING USING MULTIFUNCTIONAL BIOTIN ANALOGUES | UNIVERSITY OF NOTTINGHAM (GB) | 2010-09-23 | — | — | WO | disclosed |
| US-20090149631-A1 | Methods and compositions for protein labeling using lipoic acid ligases | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-06-11 | — | — | US | disclosed |
| WO-2009064366-A2 | METHODS AND COMPOSITIONS FOR PROTEIN LABELING USING LIPOIC ACID LIGASES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-05-22 | — | — | WO | disclosed |
| US-20090030261-A1 | DRUG DELIVERY SYSTEM | LUMEMED LIMITED (GB) | 2009-01-29 | — | — | US | disclosed |
| US-7172877-B2 | Methods and compositions for peptide and protein labeling | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-02-06 | — | — | US | disclosed |
| US-20050233389-A1 | Methods and compositions for peptide and protein labeling | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2005-10-20 | — | — | US | disclosed |
| US-20040209317-A1 | Methods and compositions for peptide and protein labeling | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050233389-A1 | Methods and compositions for peptide and protein labeling | HLCS, BTD, QPCTL | NPSR1 2241/4885ALDH1A1 4372/4885TSHR 2934/4885 |
| US-20090149631-A1 | Methods and compositions for protein labeling using lipoic acid ligases | HLCS, ACSL5, ACSL1 | NPSR1 4319/4885ALDH1A1 2093/4885TSHR 4081/4885 |
| US-20210196842-A1 | SITE-SPECIFIC RADIOFLUORINATION OF PEPTIDES WITH 8-[18F]-FLUOROOCTANOIC ACID CATALYZED BY LIPOIC ACID LIGASE | DLAT, FABP7, ACSL1 | NPSR1 3699/4885ALDH1A1 1130/4885TSHR 1871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.