Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL381002 | 0.91 | L3MBTL1 (0.39) | RAD52UBE2NL3MBTL1HDAC4KCNH2 | |
| SCHEMBL14391384 | 0.88 | PARP1 (0.38) | L3MBTL1ERN1HRH3PKMJAK2 | |
| SCHEMBL209661 | 0.87 | PKM (0.44) | ERN1HRH3PKMMETJAK2 | |
| SCHEMBL209660 | 0.87 | PKM (0.44) | ERN1HRH3PKMMETJAK2 | |
| SCHEMBL13072734 | 0.87 | HTR2B (0.37) | RAD52UBE2NL3MBTL1KCNH2TPSAB1 | |
| Trifluoroacetic Acid SCHEMBL381532 | 0.86 | PRCP (0.38) | KCNH2CHRM2CHRM1CHRM3 | |
| Trifluoroacetic Acid SCHEMBL381380 | 0.86 | TP53 (0.39) | CHRM2CHRM1CHRM3 | |
| SCHEMBL207860 | 0.86 | BMPR1B (0.43) | L3MBTL1ERN1HRH3PKMPHGDH | |
| SCHEMBL381728 | 0.85 | NPY1R (0.37) | RAD52UBE2NL3MBTL1KCNH2MET | |
| SCHEMBL381727 | 0.85 | NPY1R (0.37) | RAD52UBE2NL3MBTL1KCNH2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049513-B1 | PIPERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-01-25 | — | — | EP | disclosed |