Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.38 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
| ▸ | CSF1R | P07333 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | FLT1 | P17948 | 3/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.38 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379502 | 0.83 | SLC6A2 (0.33) | KDRAURKBAURKA | |
| SCHEMBL380010 | 0.81 | KDR (0.43) | KDRAURKBAURKAMAP4K4LCK | |
| SCHEMBL2369059 | 0.81 | FGFR1 (0.56) | KDRAURKBAURKAMAP4K4LCK | |
| SCHEMBL2900100 | 0.77 | FGFR1 (0.47) | KDRAURKBAURKAMAP4K4LCK | |
| SCHEMBL3387889 | 0.76 | LMNA (0.50) | KDRMAP4K4LCKCSF1RFGFR1 | |
| SCHEMBL3381246 | 0.74 | LMNA (0.43) | KDRMAP4K4LCKCSF1RFGFR1 | |
| SCHEMBL2368941 | 0.74 | LMNA (0.43) | KDRMAP4K4LCKCSF1RFGFR1 | |
| SCHEMBL2368911 | 0.73 | LMNA (0.45) | KDRMAP4K4LCKCSF1RFGFR1 | |
| SCHEMBL3383431 | 0.73 | ALDH1A1 (0.44) | KDRMAP4K4LCKCSF1RFGFR1 | |
| SCHEMBL3387596 | 0.73 | LMNA (0.42) | KDRAURKBAURKAMAP4K4LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968982-B1 | THIENO (3,2-C) PYRIDINE COMPOUNDS | XENTION LTD (GB) | 2012-01-25 | — | — | EP | claimed |