Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.55 |
| ▸ | CDC7 | O00311 | 12/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 12/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 12/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.35 |
| ▸ | CDK2 | P24941 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3494101 | 0.82 | PDE5A (0.55) | PDE5ARAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL3491807 | 0.79 | PDE5A (0.56) | PDE5ARAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL38005 | 0.77 | PDE5A (0.69) | PDE5ACDC7ROCK1DBF4CCNE1 | |
| SCHEMBL37513 | 0.76 | PDE5A (0.79) | PDE5ACDC7ROCK1DBF4CCNE1 | |
| SCHEMBL37942 | 0.76 | PDE5A (0.78) | PDE5ARAB9ALMNASMN1; SMN2KDM4E | |
| SCHEMBL44227 | 0.76 | PDE5A (0.67) | PDE5ACDC7ROCK1DBF4CCNE1 | |
| SCHEMBL37536 | 0.73 | PDE5A (0.60) | PDE5ACDC7ROCK1DBF4CCNE1 | |
| SCHEMBL37981 | 0.73 | PDE5A (0.66) | PDE5ACDC7ROCK1DBF4CCNE1 | |
| SCHEMBL38116 | 0.73 | PDE5A (0.63) | PDE5ARAB9ALMNASMN1; SMN2KDM4E | |
| SCHEMBL3491341 | 0.72 | ALDH1A1 (0.52) | RAB9ASMN1; SMN2ALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |