Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.33 |
| ▸ | SPR | P35270 | 3/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | CCR3 | P51677 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL381544 | 0.90 | NAMPT (0.38) | NAMPTALDH1A1SMN1; SMN2METP2RX7 | |
| SCHEMBL381545 | 0.90 | NAMPT (0.38) | NAMPTALDH1A1SMN1; SMN2METP2RX7 | |
| SCHEMBL381543 | 0.88 | NAMPT (0.36) | NAMPTMETP2RX7HRH3SPR | |
| SCHEMBL381542 | 0.88 | NAMPT (0.36) | NAMPTMETP2RX7HRH3SPR | |
| SCHEMBL13031218 | 0.86 | MET (0.36) | NAMPTSMN1; SMN2METSPRHTR2B | |
| SCHEMBL381499 | 0.86 | MCHR1 (0.34) | HRH3MGLL | |
| SCHEMBL381332 | 0.86 | MCHR1 (0.34) | HRH3MGLL | |
| SCHEMBL208372 | 0.86 | HSD11B1 (0.41) | NAMPTALDH1A1METSPRHTR2B | |
| SCHEMBL381812 | 0.86 | CHRM3 (0.33) | — | |
| SCHEMBL381094 | 0.85 | HDAC4 (0.41) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049513-B1 | PIPERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-01-25 | — | — | EP | claimed |