Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | LIPE | Q05469 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CPS1 | P31327 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14389754 | 0.81 | GPR119 (0.47) | LIPEGAANPY2RMGLL | |
| SCHEMBL1244446 | 0.80 | MGLL (0.43) | NPC1RAB9ALIPESMN1; SMN2MAPT | |
| SCHEMBL18343897 | 0.77 | NPC1 (0.68) | NPC1RAB9ALIPESMN1; SMN2MAPT | |
| SCHEMBL5650613 | 0.77 | NPC1 (0.68) | NPC1RAB9ALIPESMN1; SMN2MAPT | |
| SCHEMBL6880743 | 0.76 | NPC1 (0.88) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8480175 | 0.75 | NPC1 (1.00) | NPC1RAB9ALIPESMN1; SMN2MEN1 | |
| SCHEMBL30865732 | 0.73 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL30594488 | 0.72 | KMT2A (0.68) | NPC1RAB9ALIPEMEN1KMT2A | |
| SCHEMBL2103545 | 0.72 | CYP1A2 (0.70) | NPC1RAB9AFAAHMGLLCYP1A2 | |
| SCHEMBL4780064 | 0.72 | ALOX15 (0.56) | NPC1RAB9ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |