Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3809448 | 0.92 | LTB4R2 (0.38) | NR1H4LTB4R2MEN1KMT2A | |
| SCHEMBL3814874 | 0.92 | LTB4R2 (0.40) | NR1H4LTB4R2RAB9AOPRM1OPRD1 | |
| SCHEMBL3812570 | 0.89 | LTB4R2 (0.39) | NR1H4LTB4R2RAB9A | |
| SCHEMBL3816717 | 0.87 | NR1H4 (0.51) | NR1H4PTGESALOX5 | |
| SCHEMBL2158025 | 0.87 | PTGES (0.42) | NR1H4PTGESALOX5LTB4R2RAB9A | |
| SCHEMBL3815608 | 0.86 | NR1H4 (0.48) | NR1H4PTGESALOX5 | |
| SCHEMBL3811640 | 0.86 | ALDH1A1 (0.38) | LTB4R2MEN1RAB9AKMT2A | |
| SCHEMBL3807347 | 0.86 | PTGES (0.43) | NR1H4PTGESALOX5LTB4R2MEN1 | |
| SCHEMBL3812096 | 0.85 | NR1H4 (0.43) | NR1H4LTB4R2MEN1RAB9AKMT2A | |
| SCHEMBL3809033 | 0.84 | PTGES (0.41) | NR1H4PTGESALOX5LTB4R2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401825-B1 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS FOR FLAVIVIRUS INFECTION | VIROCHEM PHARMA INC (CA) | 2009-08-05 | — | — | EP | claimed |